Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atovaquone (Atavaquone) 是具有口服活性的选择性寄生虫线粒体细胞色素bc1复合物的抑制剂。它抑制人类和P. falciparum 细胞色素bc1活性,IC50值分别为 460 nM 和 2.0 nM。它有抗疟作用,有潜力用于疟疾、弓形体病、肺孢子虫肺炎和巴贝斯虫病的相关研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 255 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 739 | 现货 | ||
50 mg | ¥ 1,230 | 现货 | ||
100 mg | ¥ 1,850 | 现货 | ||
200 mg | ¥ 2,750 | 现货 | ||
500 mg | ¥ 4,480 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 421 | 现货 |
产品描述 | Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. |
靶点活性 | Cytochrome bc1 (human):460 nM (IC50), Cytochrome bc1 (P. falciparum):2.0 nM (IC50) |
体外活性 | Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2] |
体内活性 | Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3] |
别名 | Atavaquone, 阿托伐醌 |
分子量 | 366.84 |
分子式 | C22H19ClO3 |
CAS No. | 95233-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.3 mg/mL (20 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.726 mL | 13.6299 mL | 27.2598 mL | 68.1496 mL |
5 mM | 0.5452 mL | 2.726 mL | 5.452 mL | 13.6299 mL | |
10 mM | 0.2726 mL | 1.363 mL | 2.726 mL | 6.815 mL | |
20 mM | 0.1363 mL | 0.6815 mL | 1.363 mL | 3.4075 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Atovaquone 95233-18-4 Metabolism Microbiology/Virology Others P450 Dehydrogenase Antibiotic Parasite CYPs Plasmodium malaria Cytochrome P450 Inhibitor Atavaquone neumocystis toxoplasmosis pneumonia 阿托伐醌 inhibit babesia inhibitor