Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atipamezole (Antisedan) 是 α2-肾上腺素受体拮抗剂,Ki=1.6 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 177 | 现货 | ||
5 mg | ¥ 393 | 现货 | ||
10 mg | ¥ 643 | 现货 | ||
25 mg | ¥ 1,150 | 现货 | ||
50 mg | ¥ 1,890 | 现货 | ||
100 mg | ¥ 2,850 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 698 | 现货 |
产品描述 | Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
靶点活性 | α2-adrenoceptor antagonist:1.6 nM(Ki) |
体外活性 | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
体内活性 | Atipamezole is well tolerated in rodents. The cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest in anesthetized, normotensive rats. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals while not necessarily on short-term working memory[1]. |
别名 | Antisedan, 阿替美唑, MPV 1248 |
分子量 | 212.29 |
分子式 | C14H16N2 |
CAS No. | 104054-27-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 39 mg/mL (183.7 mM)
Ethanol: 39 mg/mL (183.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 4.7105 mL | 23.5527 mL | 47.1054 mL | 117.7634 mL |
5 mM | 0.9421 mL | 4.7105 mL | 9.4211 mL | 23.5527 mL | |
10 mM | 0.4711 mL | 2.3553 mL | 4.7105 mL | 11.7763 mL | |
20 mM | 0.2355 mL | 1.1776 mL | 2.3553 mL | 5.8882 mL | |
50 mM | 0.0942 mL | 0.4711 mL | 0.9421 mL | 2.3553 mL | |
100 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1776 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Atipamezole 104054-27-5 GPCR/G Protein Neuroscience Adrenergic Receptor Antisedan Beta Receptor 阿替美唑 MPV 1248 MPV1248 MPV-1248 Inhibitor inhibit inhibitor