Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is an antihypertensive agent. 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Arotinolol hydrochloride 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 565 | 5日内发货 | ||
100 mg | ¥ 6,430 | 6-8周 |
Arotinolol 的其他形式现货产品:
产品描述 | Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is an antihypertensive agent. |
体外活性 | Arotinolol shows its selectivity of β-adrenergic receptors, the result of Arotinolol for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. Arotinolol shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol displaces 125I-ICYP binding to 5HT1B-receptors (pKis: 7.97 and 8.16 for β1 and β2 adrenergic receptors) [2]. |
体内活性 | Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse [1]. |
分子量 | 371.54 |
分子式 | C15H21N3O2S3 |
CAS No. | 68377-92-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (672.88 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6915 mL | 13.4575 mL | 26.915 mL | 67.2875 mL |
5 mM | 0.5383 mL | 2.6915 mL | 5.383 mL | 13.4575 mL | |
10 mM | 0.2692 mL | 1.3458 mL | 2.6915 mL | 6.7288 mL | |
20 mM | 0.1346 mL | 0.6729 mL | 1.3458 mL | 3.3644 mL | |
50 mM | 0.0538 mL | 0.2692 mL | 0.5383 mL | 1.3458 mL | |
100 mM | 0.0269 mL | 0.1346 mL | 0.2692 mL | 0.6729 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Arotinolol 68377-92-4 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit