首页 工具
登录
购物车
Anle138b

Anle138b

产品编号 T5447   CAS 882697-00-9

Anle138b 是一种毒性低,口服生物利用度高,血脑屏障通透性好的低聚物聚集抑调节剂,可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
Anle138b Chemical Structure
Anle138b, CAS 882697-00-9
规格 价格/CNY 货期 数量
1 mg ¥ 232 现货
2 mg ¥ 323 现货
5 mg ¥ 547 现货
10 mg ¥ 793 现货
25 mg ¥ 1,350 现货
50 mg ¥ 1,970 现货
100 mg ¥ 2,930 现货
200 mg ¥ 4,330 现货
500 mg ¥ 6,750 现货
1 mL * 10 mM (in DMSO) ¥ 582 现货
产品目录号及名称: Anle138b (T5447)
点击图片重新获取验证码
选择批次  
纯度: 98.76%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
体外活性 In vitro, anle138b blocked the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn), which is deposited in PD and other synucleinopathies such as dementia with Lewy bodies (DLB) and multiple system atrophy (MSA).
体内活性 Anle138b strongly inhibited all prion strains tested including BSE-derived and human prions.?Anle138b showed structure-dependent binding to pathological aggregates and strongly inhibited formation of pathological oligomers in vitro and in vivo both for prion protein and α-synuclein.?Both in mouse models of prion disease and in three different PD mouse models, anle138b strongly inhibited oligomer accumulation, neuronal degeneration, and disease progression in vivo.?Anle138b had no detectable toxicity at therapeutic doses and an excellent oral bioavailability and blood-brain-barrier penetration.
动物实验 anle138b was administered orally in DMSO/peanut butter as described above.?In a first set of experiments, 5 mg anle138b were given once daily starting either at day 80 or day 120 post i.c. infection.?Animals of each treatment group were monitored daily for signs of disease by trained animal caretakers from day 80 post infection.?The animals were sacrificed, when they had reached the terminal stage of the disease based on clinical signs (ataxia, tremor, difficulty in righting up from a position lying on its back and tail stiffness).?Typically the disease progress through the terminal stage will lead to the death of the animal within 1 or 2 days.?In addition, groups of four mice per experimental group were sacrificed at predefined time points. From all animals, one brain hemisphere and one half of the spleen were freshly frozen at 80 C for biochemical analysis.?The other hemisphere and the remaining half of the spleen as well as all inner organs were fixed in 4 % formaldehyde solution for histological analysis.?In a further experiment, treatment with anle138b was started on the day of i.c. infection with a dose of 5 mg anle138b twice daily.
分子量 343.17
分子式 C16H11BrN2O2
CAS No. 882697-00-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (145.70 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.914 mL 14.57 mL 29.1401 mL 72.8502 mL
5 mM 0.5828 mL 2.914 mL 5.828 mL 14.57 mL
10 mM 0.2914 mL 1.457 mL 2.914 mL 7.285 mL
20 mM 0.1457 mL 0.7285 mL 1.457 mL 3.6425 mL
50 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.457 mL
100 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7285 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
=
X
X
X
=
X
=
/
g/mol

输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125(6):795-813.
Ezeprogind disulfate β-Amyloid (31-35) Amyloid β Peptide (42-1)(human) acetate Pinostrobin PPI-1019 BMS 433796 Hoechst 34580 V-9-M Cholecystokinin nonapeptide

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 临床期小分子药物库 抑制剂库 抗帕金森病化合物库 NO PAINS 化合物库 药物功能重定位化合物库 已知活性化合物库 血脑屏障通透化合物库 经典已知活性库 抗阿尔茨海默症化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Anle138b 882697-00-9 Neuroscience Others Beta Amyloid Inhibitor penetration Amyloid-β pathological Abeta β-amyloid peptide modulator aggregates oligomer Anle-138b inhibit degeneration neuronal inhibitor

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼