Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ampicillin sodium (Domicillin) 是Ampicillin 的钠盐形式,是Ampicillin 的广谱半合成衍生物。它通过与青霉素结合蛋白结合来抑制细菌细胞壁的合成,从而抑制肽聚糖的合成,肽聚糖是细菌细胞壁的关键成分。
产品描述 | Ampicillin Sodium is the sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium (Domicillin) inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. |
体外活性 | Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Ampicillin inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis. |
体内活性 | Ampicillin is extremely effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[3]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[4]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[5]. |
别名 | 氨苄西林钠, Domicillin, D-(-)-α-Aminobenzylpenicillin sodium salt, Penialmen, Citteral |
分子量 | 371.39 |
分子式 | C16H18N3NaO4S |
CAS No. | 69-52-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 68 mg/mL (183.1 mM)
Ethanol: 69 mg/mL (185.8 mM)
DMSO: 35 mg/mL (94.2 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / Ethanol / DMSO | 1 mM | 2.6926 mL | 13.4629 mL | 26.9259 mL | 67.3147 mL |
5 mM | 0.5385 mL | 2.6926 mL | 5.3852 mL | 13.4629 mL | |
10 mM | 0.2693 mL | 1.3463 mL | 2.6926 mL | 6.7315 mL | |
20 mM | 0.1346 mL | 0.6731 mL | 1.3463 mL | 3.3657 mL | |
50 mM | 0.0539 mL | 0.2693 mL | 0.5385 mL | 1.3463 mL | |
H2O / Ethanol | 100 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.6731 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ampicillin sodium 69-52-3 Microbiology/Virology Antibiotic Antibacterial inhibit Inhibitor Bacterial 氨苄西林钠 Domicillin D-a-Aminobenzylpenicillin sodium Ampicillin D-(-)-α-Aminobenzylpenicillin sodium salt Penialmen D-α-Aminobenzylpenicillin sodium D-alpha-Aminobenzylpenicillin sodium Citteral inhibitor