首页 GPCR/G Protein Histamine Receptor Amodiaquine hydrochloride
Amodiaquine hydrochloride
编号 T0381     别名: Amodiaquin dihydrochloride dihydrate, Amodiaquine dihydrochloride dihydrate
CAS 6398-98-7     分子式 C20H28Cl3N3O3     分子量 464.82
靶点: histamine N-methyl transferase;
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
选择批次  
规格 库存 单价 数量
25 mg 上海现货 148.00
50 mg 上海现货 236.00
100 mg 上海现货 425.00
200 mg 上海现货 730.00
1 mL * 10 mM (in DMSO) 上海现货 164.00
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生物活性

产品描述

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.

靶点活性

histamine N-methyl transferase,18.6nM(Ki)

体外活性

体内活性

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1].

动物实验

动物模型:C57BL/6 mice

化学信息

分子量

464.82

分子式

C20H28Cl3N3O3

CAS

6398-98-7

溶解度

DMSO: 85 mg/mL (182.9 mM)

Ethanol: <1 mg/mL

Water: 27 mg/mL (58.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.151 ml 10.757 ml 21.514 ml
5 mM 0.43 ml 2.151 ml 4.303 ml
10 mM 0.215 ml 1.076 ml 2.151 ml
50 mM 0.043 ml 0.215 ml 0.43 ml
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