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Aminooxyacetic acid hemihydrochloride

Aminooxyacetic acid hemihydrochloride

产品编号 T5880   CAS 2921-14-4
别名: 氨氧基乙酸半盐酸盐, 羧甲基羟胺半盐酸盐, Carboxymethoxylamine Hemihydrochloride

Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) 是一种苹果酸-天冬氨酸穿梭 (MAS) 抑制剂,也能抑制 GABA 降解酶GABA-T。

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Aminooxyacetic acid hemihydrochloride Chemical Structure
Aminooxyacetic acid hemihydrochloride, CAS 2921-14-4
规格 价格/CNY 货期 数量
500 mg ¥ 415 现货
1 g ¥ 653 现货
1 mL * 10 mM (in DMSO) ¥ 162 现货
其他形式的 Aminooxyacetic acid hemihydrochloride:
产品目录号及名称: Aminooxyacetic acid hemihydrochloride (T5880)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
体内活性 At various intervals after aminooxyacetic acid(AOAA) the rats were either injected with one of the convulsive drugs or sacrificed for analysis of the GABA concentration.?AOAA caused a rapid initial (0-30 min) and a later slower increase of GABA in cerebellum and whole brain.?In the synaptosomal fraction the GABA accumulation was delayed and less pronounced when compared to the whole brain.?The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA.?Picrotoxin showed a somewhat different pattern to bicuculline in the interactions with AOAA.?The initial strong potentiation was not observed but the later phase of protection was present.?In the interactions with 3-MPA, the effect of AOAA was always protective.?The time to onset of convulsions was gradually increased during the first 30 min after AOAA.?This protective effect remained practically unchanged up to 6 h after AOAA.?However, once started, the convulsions were generally of the same duration and intensity.?The results can be interpreted as GABA accumulating after AOAA stimulates GABA receptors to a degree more or less proportional to the whole brain GABA concentration and further that GABA synthetized in neurons is liberated, stimulates inhibitory bicuculline sensitive (predominant) and excitatory bicuculline insensitive receptors and is captured to a large extent by non-neuronal cells[1].
别名 氨氧基乙酸半盐酸盐, 羧甲基羟胺半盐酸盐, Carboxymethoxylamine Hemihydrochloride
分子量 109.3
分子式 NH2OCH2COOH·0.5HCl
CAS No. 2921-14-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 42.9 mg/mL (392.50 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.1491 mL 45.7457 mL 91.4913 mL 228.7283 mL
5 mM 1.8298 mL 9.1491 mL 18.2983 mL 45.7457 mL
10 mM 0.9149 mL 4.5746 mL 9.1491 mL 22.8728 mL
20 mM 0.4575 mL 2.2873 mL 4.5746 mL 11.4364 mL
50 mM 0.183 mL 0.9149 mL 1.8298 mL 4.5746 mL
100 mM 0.0915 mL 0.4575 mL 0.9149 mL 2.2873 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Pagliusi S R , Gomes C , José R. Leite, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain[J]. Archiv für Experimentelle Pathologie und Pharmakologie, 1983, 322(3):210-215. 2. Korangath P , Teo W W , Sadik H , et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate[J]. Clinical Cancer Research, 2015, 21(14):3263-3273.
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相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 经典已知活性库 离子通道库 神经信号分子库 抗阿尔茨海默症化合物库 神经递质受体化合物库 已知活性化合物库 NO PAINS 化合物库 抗帕金森病化合物库 抗癌化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Aminooxyacetic acid hemihydrochloride 2921-14-4 Membrane transporter/Ion channel Neuroscience Others GABA Receptor γ-Aminobutyric acid Receptor Aminooxyacetic acid Aminooxyacetate hemihydrochloride Inhibitor inhibit 氨氧基乙酸半盐酸盐 羧甲基羟胺半盐酸盐 Carboxymethoxylamine Carboxymethoxylamine Hemihydrochloride Aminooxyacetic acid Hemihydrochloride Gamma-aminobutyric acid Receptor inhibitor

 

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