首页OthersWnkAllosteric WNK Kinase Inhibitor
Allosteric WNK Kinase Inhibitor
编号 T5456     别名: WNK-IN-11
CAS 2123489-30-3     分子式 C21H21Cl2N5OS     分子量 462.39
靶点: WNK1;
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
纯度:100.00%
规格 库存 单价 数量
2 mg 上海现货 1828.00
5 mg 上海现货 3292.00
10 mg 上海现货 5192.00
1 mL * 10 mM (in DMSO) 上海现货 3292.00
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生物活性

产品描述

WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)

靶点活性

WNK1,4 nM

体外活性

WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.

体内活性

化学信息

分子量

462.39

分子式

C21H21Cl2N5OS

CAS

2123489-30-3

溶解度

DMSO: 150 mg/mL (324.39 mM)

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.163 ml 10.813 ml 21.627 ml
5 mM 0.433 ml 2.163 ml 4.325 ml
10 mM 0.216 ml 1.081 ml 2.163 ml
50 mM 0.043 ml 0.216 ml 0.433 ml
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