Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alfuzosin hydrochloride (Alfuzosin HCl) 是一种 α1 肾上腺素受体拮抗剂,可用于良性前列腺增生(BPH)的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 255 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 739 | 现货 | ||
50 mg | ¥ 1,230 | 现货 | ||
100 mg | ¥ 1,990 | 现货 | ||
500 mg | ¥ 4,820 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 279 | 现货 |
产品描述 | Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH). |
体外活性 | Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. [1] Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine. [2] |
体内活性 | Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. [1] Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). [3] Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. [4] Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. [5] |
别名 | SL 77499-10, Alfuzosin HCl, 盐酸阿夫唑嗪 |
分子量 | 425.91 |
分子式 | C19H27N5O4·HCl |
CAS No. | 81403-68-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.7 mg/mL (25 mM)
H2O: 10.7 mg/mL (25 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.3479 mL | 11.7396 mL | 23.4791 mL | 58.6978 mL |
5 mM | 0.4696 mL | 2.3479 mL | 4.6958 mL | 11.7396 mL | |
10 mM | 0.2348 mL | 1.174 mL | 2.3479 mL | 5.8698 mL | |
20 mM | 0.1174 mL | 0.587 mL | 1.174 mL | 2.9349 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Alfuzosin hydrochloride 81403-68-1 GPCR/G Protein Neuroscience Adrenergic Receptor bladder neck inhibit Alfuzosin urination SL 77499-10 prostatic Beta Receptor Alfuzosin Hydrochloride Alfuzosin HCl Inhibitor 盐酸阿夫唑嗪 BPH inhibitor