Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alexidine dihydrochloride 对多种真菌病原体具有抗真菌和抗生物膜活性。它是一种抗癌剂,可靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1,并导致线粒体凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 257 | 现货 | ||
10 mg | ¥ 367 | 现货 | ||
25 mg | ¥ 524 | 现货 | ||
50 mg | ¥ 671 | 现货 | ||
100 mg | ¥ 970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 335 | 现货 |
产品描述 | Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Thus, Alexidine dihydrochloride has the potential to be developed as a pan-antifungal, antibiofilm drug. |
体外活性 | Alexidine dihydrochloride can decimate at low concentrations (1.5 to 6 μg/mL) mature biofilms of Candida, Cryptococcus, and Aspergillus spp. that are known to be resistant to almost all classes of antifungal drugs. Alexidine dihydrochloride displays activity against most Candida spp.; MIC values of ≤1.5 μg/mL are observed for all isolates tested under planktonic conditions, with the exception of Candida parapsilosis and Candida krusei and it also displays striking activity against clinically relevant fluconazole-resistant Candida isolates: C. albicans (CA2, CA6, and CA10), C. glabrata (CG2 and CG5), C. parapsilosis (CP5), and C. auris (CAU-09 and CAU-03)[1]. Inhibition of planktonic growth by Alexidine dihydrochloride reveals a complete inhibition of filamentation or proliferation of the imaged fungi. Alexidine dihydrochloride results in 50% killing of HUVECs and lung epithelial cells, at concentrations 5- to 10-fold higher than the MIC required to kill planktonically growing fungal pathogens[1]. In fact, at 10-fold-lower concentrations (150 ng/mL) of planktonic MICs, Alexidine dihydrochloride could inhibit lateral yeast formation and biofilm dispersal in C. albicans[1]. |
体内活性 | Biofilm formation by C. Albicans is chosen to focus on because a murine biofilm model has been well established in this fungus and used for testing the effects of established and new antifungal agents. In fact, fungal CFU determination reveals that Alexidine dihydrochloride inhibits 67% of fungal biofilm growth and viability, compared to the control untreated biofilms[1]. The effect of the drugs on the 24-h-old biofilms growing in the jugular vein catheters of mice is visualized microscopically, which reveals significantly lower density of the biofilms in catheters treated with Alexidine dihydrochloride. |
分子量 | 581.71 |
分子式 | C26H58Cl2N10 |
CAS No. | 1715-30-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (429.77 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7191 mL | 8.5953 mL | 17.1907 mL | 42.9767 mL |
5 mM | 0.3438 mL | 1.7191 mL | 3.4381 mL | 8.5953 mL | |
10 mM | 0.1719 mL | 0.8595 mL | 1.7191 mL | 4.2977 mL | |
20 mM | 0.086 mL | 0.4298 mL | 0.8595 mL | 2.1488 mL | |
50 mM | 0.0344 mL | 0.1719 mL | 0.3438 mL | 0.8595 mL | |
100 mM | 0.0172 mL | 0.086 mL | 0.1719 mL | 0.4298 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Alexidine dihydrochloride 1715-30-6 Apoptosis Microbiology/Virology Others Antifungal anticancer antibiofilm Fungal mitochondrial AXD antifungal phosphatase Alexidine Dihydrochloride tyrosine inhibit PTPMT1 Alexidine Inhibitor inhibitor