Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alectinib hydrochloride (RO5424802 Hydrochloride) 是一种有效的、选择性的、口服具有活力的、ATP 竞争性的 ALK 抑制剂,其IC50=1.9 nM,Kd=2.4 nM,并且还抑制ALK F1174L 和ALK R1275Q,其IC50分别为 1 nM 和 3.5 nM。它还有中枢神经系统渗透能力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 233 | 现货 | ||
5 mg | ¥ 368 | 现货 | ||
10 mg | ¥ 517 | 现货 | ||
25 mg | ¥ 775 | 现货 | ||
50 mg | ¥ 988 | 现货 | ||
100 mg | ¥ 1,630 | 现货 | ||
500 mg | ¥ 3,970 | 现货 |
产品描述 | Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM) |
靶点活性 | ALK:1.9 nM |
体内活性 | Alectinib hydrochloride(CH5424802), a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo |
动物实验 | Animal Model:SCID or nude mice bearing NCI-H2228 cells. Dosage:0.2 mg/kg, 0.6 mg/kg, 2 mg/kg, 6 mg/kg, 20 mg/kg. Administration:Oral administration; once daily; for 11 days |
别名 | 艾乐替尼盐酸盐, CH5424802 (Hydrochloride), AF-802 (Hydrochloride), RO5424802 (Hydrochloride) |
分子量 | 519.08 |
分子式 | C30H35ClN4O2 |
CAS No. | 1256589-74-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (11.56 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9265 mL | 9.6324 mL | 19.2649 mL | 48.1621 mL |
5 mM | 0.3853 mL | 1.9265 mL | 3.853 mL | 9.6324 mL | |
10 mM | 0.1926 mL | 0.9632 mL | 1.9265 mL | 4.8162 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Alectinib hydrochloride 1256589-74-8 Angiogenesis Tyrosine Kinase/Adaptors ALK Cluster of differentiation 246 艾乐替尼盐酸盐 CH-5424802 RO 5424802 AF-802 Alectinib Hydrochloride inhibit Inhibitor CH5424802 (Hydrochloride) AF802 Alectinib RO5424802 RO-5424802 CH 5424802 ALK tyrosine kinase receptor AF-802 (Hydrochloride) RO5424802 (Hydrochloride) Anaplastic lymphoma kinase CD246 CH5424802 Anaplastic lymphoma kinase (ALK) AF 802 inhibitor