store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adrenochrome (Adraxone) 是一种细胞毒性分子,可用于杀死细菌。Adrenochrome 是 Epinephrine 的氧化产物。Adrenochrome 是一种可作用于大鼠心脏的冠状动脉收缩化合物,与心脏毒性有关,可用于确定超氧化物歧化酶的活性。Adrenochrome 与可用于神经系统疾病研究,是拟精神病的潜在药物。
产品描述 | Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associated with cardiotoxicity and can be used to determine superoxide dismutase activity. Adrenochrome is a potential psychotropic drug for the study of nervous system diseases. |
体外活性 | Microsomal calcium binding, calcium uptake, and Ca2+-stimulated Mg2+-dependent ATPase activities are reduced in the presence of Adrenochrome. The inhibitory impact of Adrenochrome on microsomal calcium uptake activity of the isolated membrane remains unaffected by various factors, including pH (ranging from 6.0 to 8.0), calcium concentrations (ranging from 10 to 200 μM), protein concentration (ranging from 0.02 to 0.10 mg/mL), temperature (ranging from 25 to 37 degrees C), and incubation time (ranging from 2 to 30 minutes). [1] |
体内活性 | In isolated rat hearts, the administration of Adrenochrome at concentrations ranging from 1 to 1000 ng/mL leads to a dose- and time-dependent elevation in coronary pressure. Moreover, the extent of constriction induced by Adrenochrome is influenced by the concentration of CaCl2 in the perfusion medium. [2] |
别名 | Adraxone |
分子量 | 179.17 |
分子式 | C9H9NO3 |
CAS No. | 54-06-8 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (502.3 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 5.5813 mL | 27.9065 mL | 55.8129 mL | 139.5323 mL |
5 mM | 1.1163 mL | 5.5813 mL | 11.1626 mL | 27.9065 mL | |
10 mM | 0.5581 mL | 2.7906 mL | 5.5813 mL | 13.9532 mL | |
20 mM | 0.2791 mL | 1.3953 mL | 2.7906 mL | 6.9766 mL | |
50 mM | 0.1116 mL | 0.5581 mL | 1.1163 mL | 2.7906 mL | |
100 mM | 0.0558 mL | 0.2791 mL | 0.5581 mL | 1.3953 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Adrenochrome 54-06-8 oxidation-reduction Antioxidant Adraxone Inhibitor inhibitor inhibit