首页 GPCR/G Protein Histamine Receptor Acrivastine
Acrivastine
编号 T4551     别名: BW825C, Semprex, Acrivastin, Semprex, BW825C, Acrivastin
CAS 87848-99-5     分子式 C22H24N2O2     分子量 348.44
靶点:
Acrivastine is a short-acting histamine 1 receptor antagonist.
选择批次  
规格 库存 单价 数量
5 mg 上海现货 284.00
10 mg 上海现货 462.00
25 mg 上海现货 1028.00
50 mg 上海现货 1585.00
100 mg 上海现货 2265.00
1 mL * 10 mM (in DMSO) 上海现货 284.00
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生物活性

产品描述

Acrivastine is a short-acting histamine 1 receptor antagonist.

靶点活性

体外活性

体内活性

Acrivastine (usually 8mg three times daily) is an effective and well-tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine causes less drowsiness than clemastine, the incidence of adverse effects being indistinguishable from that with placebo or terfenadine. In the treatment of dermatoses in which histamine has a pathogenetic role, the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine, hydroxyzine, chlorpheniramine, cyproheptadine or terfenadine [1]. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing, running nose and the calculated overall score. In addition, 8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis [2].

化学信息

分子量

348.44

分子式

C22H24N2O2

CAS

87848-99-5

溶解度

DMSO: 10 mg/mL, warmed&ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.87 ml 14.35 ml 28.699 ml
5 mM 0.574 ml 2.87 ml 5.74 ml
10 mM 0.287 ml 1.435 ml 2.87 ml
50 mM 0.057 ml 0.287 ml 0.574 ml
相关化合物库
本产品收录于以下化合物库中:
  • 上市药物库
  • 经典已知活性库
  • FDA 上市药物库
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