Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂,可用于炎症研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 378 | 现货 | ||
2 mg | ¥ 548 | 现货 | ||
5 mg | ¥ 878 | 现货 | ||
10 mg | ¥ 1,210 | 现货 | ||
25 mg | ¥ 2,450 | 现货 | ||
50 mg | ¥ 3,930 | 现货 | ||
100 mg | ¥ 5,630 | 现货 | ||
500 mg | ¥ 11,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 983 | 现货 |
产品描述 | Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor. |
体外活性 | Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2]. |
激酶实验 | Rolapitant is made at a stock concentration of 1 mM in 100% DMSO. For most receptor binding studies, the stock solution is diluted with the final concentrations ranged from 0.1 to 3 μM. Radioligand concentrations for competition binding studies ranged from 0.5 to 1 nM. For species comparison studies, 150 pM [125I]-BHSP is incubated with varying concentrations of protein (10-50 μg) prepared from gerbil, rabbit and monkey striata, and from cells expressing cloned rat, mouse and guinea pig NK receptors[1]. |
别名 | 阿西鲁司特, CTX-4430 |
分子量 | 481.54 |
分子式 | C29H27N3O4 |
CAS No. | 943764-99-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
Methanol: 32 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0767 mL | 10.3834 mL | 20.7667 mL | 51.9168 mL |
5 mM | 0.4153 mL | 2.0767 mL | 4.1533 mL | 10.3834 mL | |
10 mM | 0.2077 mL | 1.0383 mL | 2.0767 mL | 5.1917 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Acebilustat 943764-99-6 Immunology/Inflammation Metabolism Aminopeptidase LTR 阿西鲁司特 CTX 4430 Inhibitor inhibit CTX4430 CTX-4430 inhibitor