Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASP-4058 是一种鞘氨醇磷酸受体 1 和 5 (S1P1 and S1P5) 的二代激动剂,具有选择性、安全性和口服活性。ASP-4058能改善小鼠实验性自身免疫性脑脊髓炎。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,150 | 现货 | ||
5 mg | ¥ 2,930 | 现货 | ||
10 mg | ¥ 4,350 | 现货 | ||
25 mg | ¥ 6,950 | 现货 | ||
50 mg | ¥ 9,390 | 现货 | ||
100 mg | ¥ 12,600 | 现货 | ||
500 mg | ¥ 25,300 | 现货 |
产品描述 | ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice. |
体外活性 | ASP4058 (100 nM) significantly reduced FITC-dextran leakage through an endothelial monolayer and suppressed the migration of macrophages across the monolayer in vitro by using a Transwell system.[2] |
体内活性 |
ASP4058 (0.1 and 0.3 mg/kg; p.o.; daily for day 12 to day 45) maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 value for ASP4058 is 0.063 mg/kg.[1] ASP4058 (0.03, 0.1, and 0.3 mg/kg; p.o., daily for 21 days) reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1, and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of the vehicle-treated group is 15.5±0.619 in rats.[1] |
分子量 | 442.31 |
分子式 | C19H12F6N4O2 |
CAS No. | 952565-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (101.7 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2609 mL | 11.3043 mL | 22.6086 mL | 56.5214 mL |
5 mM | 0.4522 mL | 2.2609 mL | 4.5217 mL | 11.3043 mL | |
10 mM | 0.2261 mL | 1.1304 mL | 2.2609 mL | 5.6521 mL | |
20 mM | 0.113 mL | 0.5652 mL | 1.1304 mL | 2.8261 mL | |
50 mM | 0.0452 mL | 0.2261 mL | 0.4522 mL | 1.1304 mL | |
100 mM | 0.0226 mL | 0.113 mL | 0.2261 mL | 0.5652 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ASP-4058 952565-91-2 GPCR/G Protein S1P Receptor LPL Receptor ASP4058 ASP 4058 Inhibitor inhibitor inhibit