Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 4,570 | 8-10周 | ||
25 mg | ¥ 14,300 | 8-10周 | ||
50 mg | ¥ 18,700 | 8-10周 | ||
100 mg | ¥ 25,500 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,930 | 8-10周 |
产品描述 | AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2]. |
靶点活性 | RARβ:2 nM (kd), RARγ:5 nM (kd), RARα:3 nM (kd) |
体外活性 | AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells[2]. AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB[2]. AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis[2]. |
体内活性 | AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310[3]. |
别名 | VTP-194310 |
分子量 | 424.55 |
分子式 | C28H24O2S |
CAS No. | 229961-45-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (117.77 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3554 mL | 11.7772 mL | 23.5544 mL | 58.8859 mL |
5 mM | 0.4711 mL | 2.3554 mL | 4.7109 mL | 11.7772 mL | |
10 mM | 0.2355 mL | 1.1777 mL | 2.3554 mL | 5.8886 mL | |
20 mM | 0.1178 mL | 0.5889 mL | 1.1777 mL | 2.9443 mL | |
50 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1777 mL | |
100 mM | 0.0236 mL | 0.1178 mL | 0.2355 mL | 0.5889 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AGN 194310 229961-45-9 Metabolism Retinoid Receptor VTP-194310 AGN-194310 AGN194310 VTP 194310 VTP194310 Inhibitor inhibitor inhibit