Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
AE0047 Hydrochloride 的其他形式现货产品:
产品描述 | AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease. |
体外活性 | AE0047 Hydrochloride (4e) is an antagonist of calcium[1]. AE0047 inhibits [3H]nimodipine binding to rat cardiac membrane homogenate (IC50 of 0.26 nM)[2]. AE0047 (1 μM) inhibits the high K+-evoked vascular smooth muscle contraction, and also inhibits [3H]PN200-110 binding (Ki : 40.9 nM)[3]. |
体内活性 | AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure(ED30 of 1.1 mg/kg)[2].In aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP), AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine [4]. |
分子量 | 723.26 |
分子式 | C41H43ClN4O6 |
CAS No. | 116308-56-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AE0047 Hydrochloride 116308-56-6 Membrane transporter/Ion channel Metabolism Calcium Channel AE 0047 Hydrochloride AE-0047 Hydrochloride Inhibitor inhibitor inhibit