Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-385358 是一种特异性 Bcl-xL 抑制剂,对 Bcl-xL 和 Bcl-2 的 Ki 分别为 0.80 nM 和 67 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 651 | 现货 | ||
5 mg | ¥ 1,460 | 现货 | ||
10 mg | ¥ 2,130 | 现货 | ||
25 mg | ¥ 3,580 | 现货 | ||
50 mg | ¥ 5,170 | 现货 | ||
100 mg | ¥ 7,320 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 现货 |
产品描述 | A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively. |
靶点活性 | BCL-XL:0.8 nM (ki), BCL2:67 nM (ki) |
体外活性 | In IL-3-deprived FL5.12/Bcl-XL cells, A-385358 results in cell killing with an EC50 of 0.47 μM and increases caspase-3 activity. The EC50 of A-385358 for IL-3-depleted FL5.12/Bcl-2 cells with an EC50 of 1.9 μM which is 4-fold higher relative to the cytokine-deprived FL5.12/Bcl-XL cells. A-385358 stimulates more cytochrome c release from mitochondria isolated from FL5.12/Bcl-XL versus Bcl-2 cells[1]. |
体内活性 | The combination of A-385358 (75 mg/kg) plus paclitaxel (30 mg/kg) is well tolerated and inhibits tumor growth rate by nearly 80%. A-385358 exhibits slow but steady increase in the tumor growth. The combination of A-385358 (100 mg/kg) and a lower dose of paclitaxel produces a significant reduction in tumor growth and yields a >100% increase in time for tumors to reach 900 mm3 (%ILS)[1]. |
分子量 | 639.83 |
分子式 | C32H41N5O5S2 |
CAS No. | 406228-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (70.33 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5629 mL | 7.8146 mL | 15.6292 mL | 39.0729 mL |
5 mM | 0.3126 mL | 1.5629 mL | 3.1258 mL | 7.8146 mL | |
10 mM | 0.1563 mL | 0.7815 mL | 1.5629 mL | 3.9073 mL | |
20 mM | 0.0781 mL | 0.3907 mL | 0.7815 mL | 1.9536 mL | |
50 mM | 0.0313 mL | 0.1563 mL | 0.3126 mL | 0.7815 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
A-385358 406228-55-5 Apoptosis BCL Bcl-2 Family Inhibitor A 385358 A385358 inhibit inhibitor