Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 2,570 | 5日内发货 | ||
5 mg | ¥ 2,890 | 5日内发货 | ||
25 mg | ¥ 12,400 | 8-10周 | ||
50 mg | ¥ 16,200 | 8-10周 | ||
100 mg | ¥ 23,300 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,170 | 5日内发货 |
产品描述 | A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM. |
靶点活性 | TRPV1 (human):9 nM |
体外活性 | A-1165442 displays potent, competitive antagonism at recombinant human TRPV1 activated by capsaicin (IC50=9 nM) and incomplete blockade of acid-evoked response (62% block at 30 μM). A-1165442 possesses excellent selectivity (>100-fold) versus other members of the TRP family (TRPA1, TRPM8, TRPV2, TRPV3) and other receptors expressed in peripheral sensory neurons including P2X2/3, Cav2.2, Nav channels, and KCNQ2/3. A-1165442 shows minimal cross-reactivity upon evaluation (10 μM) in a broad screening panel (n=74, CEREP) of cell-surface receptors, ion channels, and enzymes[1]. |
体内活性 | A-1165442 exhibits excellent pharmacological selectivity, has a favorable pharmacokinetic profile, and demonstrates good efficacy against osteoarthritis pain in rodents. Oral administration of A-1165442 prevents capsaicin-induced nocifensive behaviors in rats, with an ED50 of 9.5 μmol/kg corresponding to plasma concentration of 420 ng/mL (970 nM). A single dose of A-1165442 produces a robust effect on grip force, with an ED50 of 35 μmol/kg measured 1 h postdosing. Repeated dosing of A-1165442 results in an increase in potency relative to acute analgesic efficacy. No significant changes in core body temperature is observed in conscious rats dosed with A-1165442 and this temperature-neutral profile is maintained in conscious dogs[1]. |
分子量 | 431.86 |
分子式 | C22H20ClF2N3O2 |
CAS No. | 1221443-94-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (231.56 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3156 mL | 11.5778 mL | 23.1557 mL | 57.8891 mL |
5 mM | 0.4631 mL | 2.3156 mL | 4.6311 mL | 11.5778 mL | |
10 mM | 0.2316 mL | 1.1578 mL | 2.3156 mL | 5.7889 mL | |
20 mM | 0.1158 mL | 0.5789 mL | 1.1578 mL | 2.8945 mL | |
50 mM | 0.0463 mL | 0.2316 mL | 0.4631 mL | 1.1578 mL | |
100 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5789 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
A-1165442 1221443-94-2 Membrane transporter/Ion channel TRP/TRPV Channel A1165442 A 1165442 Inhibitor inhibitor inhibit