Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A 582941 HCl (848591-90-2(free base)) 是一种具有广谱认知增强特性的 alpha7 神经元烟碱受体激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,320 | 现货 | ||
25 mg | ¥ 6,890 | 现货 | ||
50 mg | ¥ 9,330 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,790 | 现货 |
产品描述 | A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties |
体外活性 | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1]. |
分子量 | 316.83 |
分子式 | C17H21ClN4 |
CAS No. | T8725 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (37.88 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1563 mL | 15.7813 mL | 31.5627 mL | 78.9067 mL |
5 mM | 0.6313 mL | 3.1563 mL | 6.3125 mL | 15.7813 mL | |
10 mM | 0.3156 mL | 1.5781 mL | 3.1563 mL | 7.8907 mL | |
20 mM | 0.1578 mL | 0.7891 mL | 1.5781 mL | 3.9453 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
A 582941 HCl (848591-90-2(free base)) T8725 Neuroscience AChR A 582941 HCl (848591902(free base)) A 582941 HCl (848591 90 2(free base)) Inhibitor inhibitor inhibit