Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-ING-41 是基于马来酰亚胺的 ATP 竞争性和选择性的糖原合酶激酶-3β 抑制剂,IC50为 0.71 μM。它显著导致癌细胞的细胞周期停滞,自噬和凋亡,具有增强化疗药物抗肿瘤作用的潜力,有抗癌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 432 | 现货 | ||
2 mg | ¥ 623 | 现货 | ||
5 mg | ¥ 927 | 现货 | ||
10 mg | ¥ 1,650 | 现货 | ||
25 mg | ¥ 3,490 | 现货 | ||
50 mg | ¥ 4,970 | 现货 | ||
100 mg | ¥ 7,230 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 997 | 现货 |
产品描述 | 9-ING-41 is a glycogen synthase kinase-3 inhibitor. |
靶点活性 | GSK-3β:0.71 μM (IC50) |
体外活性 | 9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2]. |
体内活性 | In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity [2]. |
分子量 | 404.35 |
分子式 | C22H13FN2O5 |
CAS No. | 1034895-42-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 97 mg/mL (239.89mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4731 mL | 12.3655 mL | 24.731 mL | 61.8276 mL |
5 mM | 0.4946 mL | 2.4731 mL | 4.9462 mL | 12.3655 mL | |
10 mM | 0.2473 mL | 1.2366 mL | 2.4731 mL | 6.1828 mL | |
20 mM | 0.1237 mL | 0.6183 mL | 1.2366 mL | 3.0914 mL | |
50 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2366 mL | |
100 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6183 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
9-ING-41 1034895-42-5 Apoptosis Autophagy PI3K/Akt/mTOR signaling Stem Cells GSK-3 cycle cell inhibit 9ING41 Inhibitor Glycogen synthase kinase 3 9 ING 41 arrest Glycogen synthase kinase-3 anticancer GSK-3β activity inhibitor