Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-prenylnaringenin 是一种从啤酒花穗中分离到的异戊烯类黄酮,具有细胞毒性。它能通过激活小鼠 Akt 磷酸化途径,使其从静止诱导的停用性肌肉萎缩中恢复。它能通过诱导内源性和外源性通路介导的凋亡,对 HCT-116 结肠癌细胞产生抗增殖活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 868 | 现货 | ||
5 mg | ¥ 2,230 | 现货 | ||
10 mg | ¥ 3,330 | 现货 | ||
25 mg | ¥ 5,330 | 现货 | ||
50 mg | ¥ 7,290 | 现货 | ||
100 mg | ¥ 9,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,230 | 现货 |
产品描述 | 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, |
体外活性 | In vitro, aggregates of buccal epithelial cells were irradiated and cultured in suspension for 11 days. 8-PN or TAM were investigated regarding their effect on cell shedding. In vivo, the lower tongue surface of mice was irradiated with graded single doses of 25 kV X-rays. The incidence, latency, and duration of the resulting mucosal ulcerations were analyzed after topical treatment with 8-PN, TAM or solvent. 8-PN or TAM prevented the volume reduction of the irradiated cell aggregates during the incubation period. This was the result of a higher residual cell number in the treated versus the untreated irradiated aggregates. In vivo, topical treatment with 8-PN or TAM significantly increased the latency of mucositis from 10.9 to 12.1 and 12.4 days respectively, while the ulcer incidence was unchanged[1] |
别名 | 8-Prenylnaringenin, 8-异戊烯基柚皮素 |
分子量 | 340.37 |
分子式 | C20H20O5 |
CAS No. | 53846-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (66.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.938 mL | 14.6899 mL | 29.3798 mL | 73.4495 mL |
5 mM | 0.5876 mL | 2.938 mL | 5.876 mL | 14.6899 mL | |
10 mM | 0.2938 mL | 1.469 mL | 2.938 mL | 7.3449 mL | |
20 mM | 0.1469 mL | 0.7345 mL | 1.469 mL | 3.6725 mL | |
50 mM | 0.0588 mL | 0.2938 mL | 0.5876 mL | 1.469 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
8-Prenylnaringenin 53846-50-7 Apoptosis Immunology/Inflammation ROS inhibit 8Prenylnaringenin 8-Prenylnaringenin 8-?Prenylnaringenin Inhibitor 8 Prenylnaringenin 8-异戊烯基柚皮素 inhibitor