首页 Metabolism Others 7α,25-Dihydroxycholesterol
7α,25-Dihydroxycholesterol
编号 T14063     别名: 7α,25-OHC
CAS 64907-22-8     分子式 C27H46O3     分子量 418.65
靶点: Human Endogenous Metabolite; GPR183;
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
选择批次  
纯度 98.00%
规格 库存 单价 数量
1 mg 待询 1957.00
5 mg 待询 5815.00
10 mg 待询 9810.00
50 mg 待询 待询
100 mg 待询 待询
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生物活性

产品描述

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).

靶点活性

Human Endogenous Metabolite,

GPR183,

体外活性

In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells[1].

体内活性

EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment, which displays reduced homing to follicular areas of the spleen[1].

化学信息

分子量

418.65

分子式

C27H46O3

CAS

64907-22-8

溶解度

DMSO: 1 mg/mL (2.39 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.389 ml 11.943 ml 23.886 ml
5 mM 0.478 ml 2.389 ml 4.777 ml
10 mM 0.239 ml 1.194 ml 2.389 ml
50 mM 0.048 ml 0.239 ml 0.478 ml
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