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6-Methylcoumarin

产品编号 T5647 CAS 92-48-8

别名: Toncarine, 6-甲基香豆素

6-Methylcoumarin (Toncarine) 是一种合成香料，广泛用于化妆品中。

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6-Methylcoumarin, CAS 92-48-8

规格	价格/CNY	货期
500 mg	￥ 129	现货
1 g	￥ 163	现货
5 g	￥ 289	现货
10 g	￥ 413	现货
1 mL * 10 mM (in DMSO)	￥ 99	现货

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

植物来源	天然产物 > 木犀科 > 陉属
结构类型	天然产物 > 香豆素

产品描述	6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.
体外活性	Transport experiments with Caco-2 cells showed that 6MC presented high permeability at all concentrations evaluated. suggested that 6MC could be transported across the gut wall by passive diffusion
体内活性	6-Methylcoumarin(6MC) could be transported across the gut wall by passive diffusion. The maximum concentration (Cmax) was 17.13 ± 2.90 μg/mL at maximum time (Tmax) of 30 min for the oral route and Cmax 26.18 ± 2.47 μg/mL at 6.0 min for the intraperitoneal administration, with elimination constant of (Ke ) 0.0070 min-1 and a short life half time of (T1/2 ) lower that 120 min. 6MC has high accumulation in the liver, and widespread distribution in all the organs evaluated.
细胞实验	The determination of in vitro intestinal permeability of 6MC was carried out under sink conditions in a series of pH-gradient bidirectional transport experiments with Caco-2 cells. Before the experiments, cell monolayers were rinsed with Hank's balanced salt solution (HBSS) and equilibrated for 30 min at 37 °C. The integrity of the monolayers was assessed before and after the experiments, by transepithelial electrical resistance (TEER) measurement. Only monolayers with TEER values above 200 Ωcm2 were considered. A stock solution of 6MC (10 mM DMSO) was diluted to final concentration of 10, 25, 50 or 100 μM in HBSS pH 6.5 (apical transport buffer) or pH 7.4 (basolateral transport buffer). Bidirectional experiments (apical-to-basolateral [AB] and basolateral-to-apical [BA]) were initiated by adding 6MC solutions to the donor compartment, and fresh buffer to the acceptor compartment. Caco-2 cell monolayers were incubated for 1 h at 37 °C under constant stirring (150 rpm). Receiver compartments were sampled at 0, 15, 30, 45 and 60 min, refilled with an equivalent amount of transport buffer, and samples were submitted to analysis by HPLC/UV.

别名	Toncarine, 6-甲基香豆素
分子量	160.17
分子式	C10H8O2
CAS No.	92-48-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 125 mg/mL (780.42 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.2434 mL	31.2168 mL	62.4337 mL	156.0842 mL
	5 mM	1.2487 mL	6.2434 mL	12.4867 mL	31.2168 mL
	10 mM	0.6243 mL	3.1217 mL	6.2434 mL	15.6084 mL
	20 mM	0.3122 mL	1.5608 mL	3.1217 mL	7.8042 mL
	50 mM	0.1249 mL	0.6243 mL	1.2487 mL	3.1217 mL
	100 mM	0.0624 mL	0.3122 mL	0.6243 mL	1.5608 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Cárdenas Paola Andrea, Kratz Jadel Müller, Hernández Aura, et al. In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats[J]. Brazilian Journal of Pharmaceutical Sciences, 2017, 53(1).

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

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动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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