首页 Membrane transporter/Ion channel Calcium Channel 6-Methoxyluteolin
6-Methoxyluteolin
编号 TN1154    
CAS 520-11-6     分子式 C16H12O7     分子量 316.26
靶点: Calcium Channel; Histamine Receptor;
6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
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规格 库存 单价 数量
5 mg 上海现货 3660.00
10 mg 上海现货 6210.00
25 mg 上海现货 11178.00
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生物活性

产品描述

6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.

靶点活性

Calcium Channel,

Histamine Receptor,

体外活性

Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαµRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαµRI α± chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcαµRI α± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively.

体内活性

化学信息

分子量

316.26

分子式

C16H12O7

CAS

520-11-6

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.162 ml 15.81 ml 31.62 ml
5 mM 0.632 ml 3.162 ml 6.324 ml
10 mM 0.316 ml 1.581 ml 3.162 ml
50 mM 0.063 ml 0.316 ml 0.632 ml
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