Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) 修饰核碱基并掺入靶 DNA。 5-Aminouridine 抑制肿瘤、病毒和真菌的生长。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 142 | 现货 | ||
5 mg | ¥ 287 | 现货 | ||
10 mg | ¥ 407 | 现货 | ||
25 mg | ¥ 665 | 现货 | ||
50 mg | ¥ 981 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 226 | 现货 |
产品描述 | 5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi. |
体外活性 | 5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma[1]. 5-Aminouridine must exhibit a low potential to be oxidized by Os(bpy)33+. The modified nucleobase is inserted into the target DNA by direct synthesis using modified phosphoramidites[4]. |
体内活性 | 5-Aminouridine inhibits the incorporation of carbamoylaspartate into pyrimidines in living rat RNA and DNA, and the incorporation of [32P]phosphate into phospholipids and RNA nucleotides in rat liver slices and liver cancers [1]. |
别名 | 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol) |
分子量 | 259.22 |
分子式 | C9H13N3O6 |
CAS No. | 2149-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (212.17 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8577 mL | 19.2886 mL | 38.5773 mL | 96.4432 mL |
5 mM | 0.7715 mL | 3.8577 mL | 7.7155 mL | 19.2886 mL | |
10 mM | 0.3858 mL | 1.9289 mL | 3.8577 mL | 9.6443 mL | |
20 mM | 0.1929 mL | 0.9644 mL | 1.9289 mL | 4.8222 mL | |
50 mM | 0.0772 mL | 0.3858 mL | 0.7715 mL | 1.9289 mL | |
100 mM | 0.0386 mL | 0.1929 mL | 0.3858 mL | 0.9644 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
5-Aminouridine 2149-76-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Nucleoside Antimetabolite/Analog Influenza Virus Antifungal 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol) Inhibitor inhibitor inhibit