Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) 是从胡芦巴种子中提取和纯化的一种氨基酸,具有促胰岛素作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 680 | 现货 | ||
1 mL * 10 mM (in H2O) | ¥ 400 | 现货 |
产品描述 | 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity. |
体外活性 | 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity.?4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration.?The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function.?The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB[1].4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1[2]. |
别名 | 4-羟基-L-异亮氨酸, 4-Hydroxy-L-isoleucine |
分子量 | 147.17 |
分子式 | C6H13NO3 |
CAS No. | 781658-23-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL | 169.8716 mL |
5 mM | 1.359 mL | 6.7949 mL | 13.5897 mL | 33.9743 mL | |
10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | 16.9872 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
4-Hydroxyisoleucine 781658-23-9 Others Inhibitor 4-Hydroxy-L-isoleucine inhibit 4-羟基-L-异亮氨酸 4-Hydroxy-L-isoleucine 4 Hydroxyisoleucine 4Hydroxyisoleucine inhibitor