Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | 待询 | 待询 | ||
500 mg | 待询 | 待询 |
产品描述 | 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM). |
靶点活性 | β-Amyloid:ki:1.7 nM |
体内活性 | Brain entry in control mice and baboons is high for 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine. Staining of AD frontal cortex tissue sections with 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine indicates the selective binding of the compound to amyloid plaques and cerebrovascular amyloid. The brain radioactivity concentrations (%ID-kg/g) of 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is remarkably similar in mice and baboons (0.21 vs 0.27). The rate of clearance of radioactivity is considerably slower from the baboon brain than from the mouse brain, although the rank order of clearance rate is similar in mice and baboons. The tissue staining findings utilizing nonradiolabeled, fluorescent 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine are similar to those reported for BTA-1. Both amyloid plaques and cerebrovascular amyloid are stained by 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine in a manner similar to serial sections stained with an antibody to Amyloid-β, and relatively little tissue background staining is observed [1]. |
动物实验 | Studies are performed in female Swiss-Webster mice (23-35 g). The mice are injected in a lateral tail vein with 0.37-3.7 MBq (10-100 μCi) of a high specific activity (>7.4 GBq/μmol) 11C-4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine contained in <0.10 mL of a solution of 93% isotonic saline and 7% ethanol. The mice are anesthetized and killed by cardiac excision following cardiac puncture to obtain arterial blood samples at 2 or 30 min postinjection. The mouse brains are rapidly excised and divided into the cerebellum and the remaining whole brain (including brain stem) fractions. The brain samples are counted in a gamma well counter, and the counts are decay-corrected to the time of injection relative to 11C standards prepared from the injection solution to determine the percent injected dose (%ID) in the samples. The brain samples are weighed to determine the percent injected dose per gram tissue (%ID/g), and this quantity is multiplied by the whole body weight (in kg) to determine the body-weight normalized radioactivity concentration [(%ID-kg)/g] of each tissue sample [1]. |
分子量 | 319.22 |
分子式 | C14H11BrN2S |
CAS No. | 566169-98-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 Neuroscience Beta Amyloid 4 (6 Bromo 2 benzothiazolyl) N methylbenzenamine 4(6Bromo2benzothiazolyl)Nmethylbenzenamine Inhibitor inhibitor inhibit