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3-Hydroxyanthranilic acid

3-Hydroxyanthranilic acid

产品编号 T4707   CAS 548-93-6
别名: 3-HYDROXY-2-AMINOBENZOIC ACID, 3-羟基-2-氨基苯甲酸

3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID) 是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现,并且在多种生物体液中也已检测到,例如尿液和血液。在细胞内,它主要位于细胞质中。 它存在于从酵母到人类的所有真核生物中。

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3-Hydroxyanthranilic acid Chemical Structure
3-Hydroxyanthranilic acid, CAS 548-93-6
规格 价格/CNY 货期 数量
100 mg ¥ 664 现货
1 mL * 10 mM (in DMSO) ¥ 195 现货
产品目录号及名称: 3-Hydroxyanthranilic acid (T4707)
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纯度: 99.98%
纯度: 99.49%
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天然产物信息
生物活性
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存储 & 溶解度
参考文献
产品描述 3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID), also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid has been found in human epidermis and bladder tissues, and has also been detected in multiple biofluids, such as urine and blood. Within the cell, 3-hydroxyanthranilic acid is primarily located in the cytoplasm. 3-Hydroxyanthranilic acid exists in all eukaryotes, ranging from yeast to humans. 3-Hydroxyanthranilic acid participates in a number of enzymatic reactions. In particular, 3-Hydroxyanthranilic acid and L-alanine can be biosynthesized from L-3-hydroxykynurenine; which is catalyzed by the enzyme kynureninase. Furthermore, 3-Hydroxyanthranilic acid can be converted into cinnavalininate through its interaction with the enzyme catalase. Furthermore, L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine through its interaction with the enzyme kynureninase. Furthermore, 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde; which is catalyzed by the enzyme 3-hydroxyanthranilate 3,4-dioxygenase. Furthermore, 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde through the action of the enzyme 3-hydroxyanthranilate 3,4-dioxygenase. Finally, L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine; which is mediated by the enzyme kynureninase. In humans, 3-hydroxyanthranilic acid is involved in the tryptophan metabolism pathway.
别名 3-HYDROXY-2-AMINOBENZOIC ACID, 3-羟基-2-氨基苯甲酸
分子量 153.14
分子式 C7H7NO3
CAS No. 548-93-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 25 mg/mL (163.25 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.53 mL 32.6499 mL 65.2997 mL 163.2493 mL
5 mM 1.306 mL 6.53 mL 13.0599 mL 32.6499 mL
10 mM 0.653 mL 3.265 mL 6.53 mL 16.3249 mL
20 mM 0.3265 mL 1.6325 mL 3.265 mL 8.1625 mL
50 mM 0.1306 mL 0.653 mL 1.306 mL 3.265 mL
100 mM 0.0653 mL 0.3265 mL 0.653 mL 1.6325 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Antoni A D , Rubaltelli F F , Costa C , et al. Effect of phototherapy on the urinary excretion of tryptophan metabolites in neonatal hyperbilirubinemia.[J]. Acta Vitaminologica Et Enzymologica, 1975, 29(1-6):145. 2. Calandra P . Research on tryptophan metabolites "via kynurenine" in epidermis of man and mouse.[J]. Acta Vitaminol Enzymol, 1975, 29(1-6):158-160. 3. Hegedus Z L , Frank H A , Altschule M D , et al. Human plasma lipofuscin melanins formed from tryptophan metabolites[J]. Archives Internationales de Physiologie, 1986, 94(5):10. 4. Werner E R , Lutz H , Fuchs D , et al. Identification of 3-Hydroxyanthranilic Acid in Mixed Lymphocyte Cultures[J]. Biological Chemistry, 1985, 366(1):99-102. 5. Teulings F A , Mulderkooy G E , Peters H A , et al. The excretion of 3-hydroxyanthranilic acid in patients with bladder and kidney carcinoma.[J]. Acta Vitaminol Enzymol, 1975, 29(1-6):108-112.
Catechin D-glutamine Fumaric acid (S)-2-acetamido-4-amino-4-oxobutanoic acid 4,4'-Disulfanediylbis(2-aminobutanoic acid) (R)-pyrrolidine-2-carboxylic acid Prostaglandin E1 PAF (C16)

相关化合物库

该产品包含在如下化合物库中:
人内源代谢化合物库 小鼠代谢化合物库 天然产物库 高通量筛选天然产物库 人内源代谢化合物库 Plus 人代谢物化合物库 Ro5类药天然产物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

3-Hydroxyanthranilic acid 548-93-6 Metabolism Others Endogenous Metabolite 3 Hydroxyanthranilic acid 3-HYDROXY-2-AMINOBENZOIC ACID Inhibitor inhibit 3-羟基-2-氨基苯甲酸 3Hydroxyanthranilic acid inhibitor

 

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