Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性,并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 417 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 287 | 现货 |
产品描述 | 3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity. |
体外活性 | 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines (IC50 = 100 μM) and the SK-MELB cell line (IC50 = 122 μM). The IC50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line. 3,4-Dihydroxybenzylamine hydrobromide exhibits IC50values of 10, 25, 67, and 184 μM for S91A, S91B, L1210, and SCC-25 cells, respectively[1]. |
体内活性 | 3,4-Dihydroxybenzylamine hydrobromide (200, 400, 600 and 800 mg/kg; i.p.; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days respectively. 3,4-Dihydroxybenzylamine hydrobromide (1000 mg/kg; i.p.; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose[2]. |
细胞实验 | Cell Line: Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines Concentration: 1 μM-10 mM Incubation Time: 48 hours [1] |
动物实验 | Animal Model: C57BL/6 mice with B6D2F1 cells Dosage: 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg Administration: Intraperitoneal injection [2] |
别名 | NSC 263475 hydrobromide, 3,4-二羟基苄胺·氢溴酸 |
分子量 | 220.06 |
分子式 | C7H10BrNO2 |
CAS No. | 16290-26-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (363.54 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.5442 mL | 22.7211 mL | 45.4422 mL | 113.6054 mL |
5 mM | 0.9088 mL | 4.5442 mL | 9.0884 mL | 22.7211 mL | |
10 mM | 0.4544 mL | 2.2721 mL | 4.5442 mL | 11.3605 mL | |
20 mM | 0.2272 mL | 1.1361 mL | 2.2721 mL | 5.6803 mL | |
50 mM | 0.0909 mL | 0.4544 mL | 0.9088 mL | 2.2721 mL | |
100 mM | 0.0454 mL | 0.2272 mL | 0.4544 mL | 1.1361 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
3,4-Dihydroxybenzylamine hydrobromide 16290-26-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis NSC-263475 Hydrobromide Inhibitor NSC 263475 hydrobromide DNA polymerase Tumor NSC263475 melanoma NSC-263475 3,4-二羟基苄胺·氢溴酸 3,4-Dihydroxybenzylamine inhibit 3,4Dihydroxybenzylamine hydrobromide tyrosinase NSC263475 Hydrobromide NSC 263475 Hydrobromide NSC 263475 3,4-Dihydroxybenzylamine Hydrobromide 3,4 Dihydroxybenzylamine hydrobromide inhibitor