Powder: -20°C for 3 years | In solvent: -80°C for 1 year
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 417 | 现货 | ||
5 mg | ¥ 1,550 | 现货 | ||
10 mg | ¥ 2,330 | 现货 | ||
25 mg | ¥ 3,960 | 现货 | ||
50 mg | ¥ 5,650 | 现货 | ||
100 mg | ¥ 7,890 | 现货 |
产品描述 | 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
体外活性 | 27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors [1]. 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer [2]. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities [3]. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload [4]. |
别名 | 27-羟基胆固醇, 5,25R-胆甾烯-3BETA,26-二醇, 25(R)-27-hydroxy Cholesterol |
分子量 | 402.65 |
分子式 | C27H46O2 |
CAS No. | 20380-11-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 2mg/mL (4.97 mM)
DMSO: 0.1mg/mL
Ethanol: ≤ 20 mg/mL (49.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMF / Ethanol | 1 mM | 2.4835 mL | 12.4177 mL | 24.8355 mL | 62.0887 mL |
Ethanol | 5 mM | 0.4967 mL | 2.4835 mL | 4.9671 mL | 12.4177 mL |
10 mM | 0.2484 mL | 1.2418 mL | 2.4835 mL | 6.2089 mL | |
20 mM | 0.1242 mL | 0.6209 mL | 1.2418 mL | 3.1044 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
27-Hydroxycholesterol 20380-11-4 Endocrinology/Hormones Metabolism Estrogen/progestogen Receptor Liver X Receptor 27Hydroxycholesterol LXR Liver X receptor Inhibitor Estrogen Receptor/ERR Endogenous Metabolite 27-羟基胆固醇 27 Hydroxycholesterol 2527-hydroxy Cholesterol 5,25R-胆甾烯-3BETA,26-二醇 25(R)-27-hydroxy Cholesterol inhibit inhibitor