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25R-Inokosterone

25R-Inokosterone

产品编号 TN1227   CAS 19682-38-3

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.

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25R-Inokosterone Chemical Structure
25R-Inokosterone, CAS 19682-38-3
规格 价格/CNY 货期 数量
5 mg ¥ 4,750 待询
1 mL * 10 mM (in DMSO) ¥ 4,850 待询
其他形式的 25R-Inokosterone:
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
Venetoclax限时半价
产品目录号及名称: 25R-Inokosterone (TN1227)
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产品描述 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
体外活性 Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-inokosterone (2), and 25R-Inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α± plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80??95% at 200 μg/mL) against TNF-α± expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
分子量 480.642
分子式 C27H44O7
CAS No. 19682-38-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol Library Books参考文献

1. Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy ActivityJournal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.
Anti-inflammatory agent 42 α-Humulene Allicin Infliximab Varlilumab Apremilast Lasiodiplodin 7-O-Methylmorroniside

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Keywords

25R-Inokosterone 19682-38-3 Apoptosis TNF 25RInokosterone 25R Inokosterone Inhibitor inhibitor inhibit

 

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