首页 Apoptosis BCL 2-Methoxystypandrone
2-Methoxystypandrone
编号 TN2775    
CAS 85122-21-0     分子式 C14H12O5     分子量 260.2
靶点: Bcl-2; COX; GSK-3; IkB; IKK; JAK; MMP; NF-κB; NOS; p65; STAT; TNF-α; Wnt/β-catenin;
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.
选择批次  
纯度 98.00%
规格 库存 单价 数量
5 mg 待询 3864.00
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生物活性

产品描述

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

靶点活性

Bcl-2,

COX,

GSK-3,

IkB,

IKK,

JAK,

MMP,

NF-κB,

NOS,

p65,

STAT,

TNF-α,

Wnt/β-catenin,

体外活性

体内活性

化学信息

分子量

260.2

分子式

C14H12O5

CAS

85122-21-0

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.843 ml 19.216 ml 38.432 ml
5 mM 0.769 ml 3.843 ml 7.686 ml
10 mM 0.384 ml 1.922 ml 3.843 ml
50 mM 0.077 ml 0.384 ml 0.769 ml
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