Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Acetylbenzoic acid 在抑制血小板功能和血小板前列腺素 (PG) 合成方面比 2-丙酰氧基苯甲酸更有效,尽管这些药物在抑制前列环素 (PGI2) 合成方面的效力相当。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 190 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 190 | 现货 |
产品描述 | 2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis. |
体外活性 | A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-Acetylbenzoic acid had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action[1]. |
分子量 | 164.16 |
分子式 | C9H8O3 |
CAS No. | 577-56-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (335.04 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | 152.2904 mL |
5 mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | 30.4581 mL | |
10 mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 15.229 mL | |
20 mM | 0.3046 mL | 1.5229 mL | 3.0458 mL | 7.6145 mL | |
50 mM | 0.1218 mL | 0.6092 mL | 1.2183 mL | 3.0458 mL | |
100 mM | 0.0609 mL | 0.3046 mL | 0.6092 mL | 1.5229 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
2-Acetylbenzoic acid 577-56-0 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor 2 Acetylbenzoic acid 2Acetylbenzoic acid Inhibitor inhibitor inhibit