Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂,通过结合 P 位点,IC50为 3 µM。它是核苷类似物,在心脏中发挥强大的抗肾上腺素作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 338 | 现货 | ||
5 mg | ¥ 788 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,260 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,450 | 现货 | ||
500 mg | ¥ 11,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 753 | 现货 |
产品描述 | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM). |
靶点活性 | Adenylyl cyclase:3 µM |
体外活性 | 2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3]. |
体内活性 | 2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats [4]. |
细胞实验 | Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3] |
动物实验 | Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3] |
分子量 | 235.24 |
分子式 | C10H13N5O2 |
CAS No. | 6698-26-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.35 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.251 mL | 21.2549 mL | 42.5098 mL | 106.2744 mL |
5 mM | 0.8502 mL | 4.251 mL | 8.502 mL | 21.2549 mL | |
10 mM | 0.4251 mL | 2.1255 mL | 4.251 mL | 10.6274 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
2',5'-Dideoxyadenosine 6698-26-6 GPCR/G Protein Neuroscience Adenylyl cyclase Adrenergic Receptor AChR P-site 2',5'Dideoxyadenosine cyclase Beta Receptor analog heart adenylyl antiadrenergic Inhibitor Adenylate Cyclase inhibit nucleoside 2',5' Dideoxyadenosine inhibitor