Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1,4-DPCA 是一种脯氨酰羟化酶抑制剂,对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM,对因子抑制 HIF (FIH) 的 IC50 为 60 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
5 mg | ¥ 483 | 现货 | ||
10 mg | ¥ 788 | 现货 | ||
25 mg | ¥ 1,580 | 现货 | ||
50 mg | ¥ 2,490 | 现货 | ||
100 mg | ¥ 3,720 | 现货 | ||
200 mg | ¥ 5,290 | 现货 | ||
500 mg | ¥ 8,220 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 543 | 现货 |
产品描述 | 1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). |
体外活性 | 1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157[1]. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1[2]. |
体内活性 | In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity[3]. |
分子量 | 240.21 |
分子式 | C13H8N2O3 |
CAS No. | 331830-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.78 mg/mL (11.56 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.163 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
5 mM | 0.8326 mL | 4.163 mL | 8.326 mL | 20.8151 mL | |
10 mM | 0.4163 mL | 2.0815 mL | 4.163 mL | 10.4076 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
1,4-DPCA 331830-20-7 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF-PH HIF-1α HIFs FIH P4HA1 P4HA2 1,4DPCA healing Inhibitor Hypoxia-inducible factors 1,4 DPCA wound inhibit P4HA3 inhibitor