Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Lisofylline ((R)-Lisophylline) 是溶血磷脂酸酰基转移酶的抑制剂 (IC50 = 0.6 µM)。 (R)-Lisofylline 可中断 IL-12 信号介导的 STAT4 激活,可用于治疗 1 型糖尿病和自身免疫性疾病的研究。
产品描述 | (R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treatment of type 1 diabetes and autoimmune disorders. |
体外活性 | (R)-Lisofylline blocks IL-12-driven T cell proliferation and Th1 differentiation yet has no effect on IL-12 secretion[1]. |
体内活性 | In NOD mice, (R)-Lisofylline prevents β cell dysfunction by inhibition of STAT4 phosphorylation and ameliorates experimental allergic encephalomyelitis. (R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets. (R)-Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs. (R)-Lisofylline improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs[2]. |
别名 | (R)-Lisophylline |
分子量 | 280.32 |
分子式 | C13H20N4O3 |
CAS No. | 100324-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (160.53 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5674 mL | 17.8368 mL | 35.6735 mL | 89.1838 mL |
5 mM | 0.7135 mL | 3.5674 mL | 7.1347 mL | 17.8368 mL | |
10 mM | 0.3567 mL | 1.7837 mL | 3.5674 mL | 8.9184 mL | |
20 mM | 0.1784 mL | 0.8918 mL | 1.7837 mL | 4.4592 mL | |
50 mM | 0.0713 mL | 0.3567 mL | 0.7135 mL | 1.7837 mL | |
100 mM | 0.0357 mL | 0.1784 mL | 0.3567 mL | 0.8918 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(R)-Lisofylline 100324-81-0 JAK/STAT signaling Stem Cells STAT (R)-Lisophylline Pentoxifylline Inhibitor anti-inflammatory inhibit STAT4 lysophosphatidic (R)Lisofylline acid IL-12 IFN-γ diabetes immunomodulator Lisofylline (R) Lisofylline acyltransferase LPS metabolite Lisophylline inhibitor