Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ζ-Stat 是非典型的、特异性的PKC-ζ抑制剂,IC50为 5 μM。ζ-Stat 能够减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外显示除抗肿瘤活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 973 | 现货 | ||
5 mg | ¥ 2,490 | 现货 | ||
10 mg | ¥ 3,920 | 现货 | ||
25 mg | ¥ 6,280 | 现货 | ||
50 mg | ¥ 8,620 | 现货 | ||
100 mg | ¥ 11,600 | 现货 | ||
500 mg | ¥ 23,200 | 现货 |
产品描述 | ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2]. |
靶点活性 | PKCζ:5 μM |
体外活性 | ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. |
分子量 | 384.36 |
分子式 | C10H8O10S3 |
CAS No. | 3316-02-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 62.5 mg/mL (162.61 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.6017 mL | 13.0086 mL | 26.0173 mL | 65.0432 mL |
5 mM | 0.5203 mL | 2.6017 mL | 5.2035 mL | 13.0086 mL | |
10 mM | 0.2602 mL | 1.3009 mL | 2.6017 mL | 6.5043 mL | |
20 mM | 0.1301 mL | 0.6504 mL | 1.3009 mL | 3.2522 mL | |
50 mM | 0.052 mL | 0.2602 mL | 0.5203 mL | 1.3009 mL | |
100 mM | 0.026 mL | 0.1301 mL | 0.2602 mL | 0.6504 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ζ-Stat 3316-02-7 Chromatin/Epigenetic Cytoskeletal Signaling PKC antitumor NSC 37044 melanoma ζ-Stat NSC-37044 kinase NSC37044 Protein kinase C ΖStat atypical Inhibitor Apoptosis protein Ζ Stat inhibit PKC-ζ inhibitor