keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 257 | 现货 | ||
10 mg | ¥ 393 | 现货 | ||
25 mg | ¥ 659 | 现货 | ||
50 mg | ¥ 948 | 现货 | ||
100 mg | ¥ 1,330 | 现货 | ||
500 mg | ¥ 3,680 | 现货 | ||
1 g | ¥ 5,250 | 现货 |
产品描述 | β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions. |
别名 | β-NM, β烟酰胺单核苷酸, 烟酰胺单核苷酸 |
分子量 | 334.22 |
分子式 | C11H15N2O8P |
CAS No. | 1094-61-7 |
keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.992 mL | 14.9602 mL | 29.9204 mL | 74.801 mL |
5 mM | 0.5984 mL | 2.992 mL | 5.9841 mL | 14.9602 mL | |
10 mM | 0.2992 mL | 1.496 mL | 2.992 mL | 7.4801 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
β-Nicotinamide mononucleotide 1094-61-7 Metabolism Others Endogenous Metabolite Alzheimer's inhibit obesity NMN b-NM β-NM Inhibitor intermediate diabetes NAD cardioprotection β烟酰胺单核苷酸 b-Nicotinamide mononucleotide cancer βNicotinamide mononucleotide β Nicotinamide mononucleotide beta-Nicotinamide mononucleotide 烟酰胺单核苷酸 beta-NM disease inhibitor