首页 Metabolism Hydroxylase (R)-Nepicastat HCl
(R)-Nepicastat HCl
编号 T6356     别名: RS-25560-198 HCl, RS-25560-198 HCl
CAS 195881-94-8     分子式 C14H15F2N3S·HCl     分子量 331.81
靶点: Dopamine β-hydroxylase;
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
选择批次  
纯度 98.0%
规格 库存 单价 数量
2 mg 待询 656.00
5 mg 待询 1230.00
10 mg 待询 2091.00
25 mg 待询 3936.00
50 mg 待询 5330.00
100 mg 待询 7790.00
1 mL * 10 mM (in DMSO) 待询 1230.00
大包装特惠,请咨询
大包装特惠,请咨询

生物活性

产品描述

(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

靶点活性

Dopamine β-hydroxylase,25.1nM

实验溶液

30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL

体外活性

(R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1]

体内活性

(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1]

动物实验

动物模型:Animal Models Spontaneously hypertensive rats (SHRs).

化学信息

分子量

331.81

分子式

C14H15F2N3S·HCl

CAS

195881-94-8

溶解度

DMSO: 61 mg/mL (183.8 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.014 ml 15.069 ml 30.138 ml
5 mM 0.603 ml 3.014 ml 6.028 ml
10 mM 0.301 ml 1.507 ml 3.014 ml
50 mM 0.06 ml 0.301 ml 0.603 ml
技术支持
在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-998-7375,或者邮箱 info@tsbiochem.com,直接联系到我们。我们会在24小时内尽快联系您。
订购方式
联系陶素
电话:400-821-2233
传真:021-34692979
邮箱:info@tsbiochem.com


  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。