首页 GPCR/G Protein Histamine Receptor (R)-(-)-α-Methylhistamine dihydrobromide
(R)-(-)-α-Methylhistamine dihydrobromide
编号 T12630    
CAS 868698-49-1     分子式 C6H13Br2N3     分子量 287
靶点: H3 Receptor;
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
选择批次  
纯度 98.00%
规格 库存 单价 数量
100 mg 待询 待询
500 mg 待询 待询
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生物活性

产品描述

(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).

靶点活性

H3 Receptor,50.3 nM (kd)

体外活性

(R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist that is > 10 times as potent as histamine (HA).(R)-(-)-α-Methylhistamine dihydrobromide has only weak affinities for H1 and H2 receptor with a pKi=4.8 and < 3.5, repectively. Its selectivity toward H3-receptors is > 1,000 times as high as that of HA. (R)-(-)-α-Methylhistamine dihydrobromide displays >200-fold selectivity over H4 receptors[1].

体内活性

(R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4].

化学信息

分子量

287

分子式

C6H13Br2N3

CAS

868698-49-1

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.484 ml 17.422 ml 34.843 ml
5 mM 0.697 ml 3.484 ml 6.969 ml
10 mM 0.348 ml 1.742 ml 3.484 ml
50 mM 0.07 ml 0.348 ml 0.697 ml
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