store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) 是一种强效的、非特异性碱性磷酸酶抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 297 | 现货 | ||
10 mg | ¥ 497 | 现货 | ||
25 mg | ¥ 995 | 现货 | ||
50 mg | ¥ 1,370 | 现货 | ||
100 mg | ¥ 2,380 | 现货 | ||
500 mg | ¥ 5,690 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 490 | 现货 |
产品描述 | (-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase. |
体外活性 | Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3] |
别名 | (-)-对溴四咪唑草酸盐, L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate |
分子量 | 373.22 |
分子式 | C13H13BrN2O4S |
CAS No. | 62284-79-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 28 mg/mL (75 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (184.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.6794 mL | 13.3969 mL | 26.7938 mL | 66.9846 mL |
5 mM | 0.5359 mL | 2.6794 mL | 5.3588 mL | 13.3969 mL | |
10 mM | 0.2679 mL | 1.3397 mL | 2.6794 mL | 6.6985 mL | |
20 mM | 0.134 mL | 0.6698 mL | 1.3397 mL | 3.3492 mL | |
50 mM | 0.0536 mL | 0.2679 mL | 0.5359 mL | 1.3397 mL | |
DMSO | 100 mM | 0.0268 mL | 0.134 mL | 0.2679 mL | 0.6698 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(-)-p-Bromotetramisole Oxalate 62284-79-1 Metabolism Phosphatase Phosphorylase L-p-Bromotetramisole Oxalate (-)-对溴四咪唑草酸盐 L-p-Bromotetramisole oxalate ( ) p Bromotetramisole Oxalate inhibit Inhibitor ()pBromotetramisole Oxalate 6-Bromolevamisole p-Bromolevamisole Oxalate 6-Bromolevamisole oxalate (-)-p-Bromolevamisole oxalate p-Bromotetramisole Oxalate 6-Bromolevamisole Oxalate inhibitor