首页 GPCR/G Protein Histamine Receptor (±)-Tazifylline
(±)-Tazifylline
编号 T10000    
CAS 79712-55-3     分子式 C23H32N6O3S     分子量 472.6
靶点: H1-receptor;
(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
选择批次  
纯度 98.00%
规格 库存 单价 数量
100 mg 待询 待询
500 mg 待询 待询
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生物活性

产品描述

(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.

靶点活性

H1-receptor,

体外活性

Tazifylline inhibits contractions evoked by stimulation of histamine H1-receptors in isolated guinea pig ilea and exhibits high affinity for these receptors in radioligand binding studies in vitro Tazifylline has much lower affinity for histamine H2-receptors, alpha- and beta-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes.

体内活性

In rats, guinea pigs and dogs the antihistaminic effect of Tazifylline is rapid in onset and long-lived. In anesthetized guinea pigs, Tazifylline markedly inhibits histamine-induced bronchoconstriction and protects conscious animals from the lethal effect of large doses of the amine. In conscious dogs, orally administered Tazifylline inhibits histamine-induced skin inflammation for long periods of time and in anesthetized animals attenuated that portion of the histamine-evoked hypotension attributable to stimulation of H1-receptors. In conscious rats, Tazifylline is more potent in reducing the inflammatory effects of intradermal histamine than that evoked by anaphylactic reaction. Large oral doses of Tazifylline does not reduce spontaneous locomotor activity in mice, nor do they produce overt symptoms of behavioral depression in conscious rats.

化学信息

分子量

472.6

分子式

C23H32N6O3S

CAS

79712-55-3

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.116 ml 10.58 ml 21.16 ml
5 mM 0.423 ml 2.116 ml 4.232 ml
10 mM 0.212 ml 1.058 ml 2.116 ml
50 mM 0.042 ml 0.212 ml 0.423 ml
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