Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)-Tazifylline 是一种选择性的长效组胺 H1 受体拮抗剂。 Tazifylline 对 H2 受体、α- 和 β-肾上腺素能受体、5-羟色胺和毒蕈碱受体亚型的亲和力要低得多。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,370 | 现货 | ||
5 mg | ¥ 4,780 | 现货 | ||
10 mg | ¥ 6,820 | 现货 | ||
25 mg | ¥ 9,870 | 现货 | ||
50 mg | ¥ 13,700 | 现货 | ||
100 mg | ¥ 18,500 | 现货 | ||
500 mg | ¥ 36,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 5,990 | 现货 |
产品描述 | (±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor. Tazifylline shows much lower affinity for H2 receptors, α- and β-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes. |
体外活性 | Tazifylline potently inhibits contractions evoked by stimulation of histamine H1-receptors in isolated guinea pig ilea and exhibits high affinity in radioligand binding studies[1]. |
体内活性 | In anesthetized guinea pigs, Tazifylline causes an inhibition in histamine-induced bronchoconstriction and protects conscious animals from the lethal effect of large doses of the amine. In conscious rats, Tazifylline reduces the inflammatory effects of intradermal histamine. In conscious dogs, Tazifylline(orally) causes inhibition in histamine-induced skin inflammation for long periods of time, and in anesthetized animals attenuated that portion of the histamine-evoked hypotension attributable to stimulation of H1 receptors. Large oral doses of Tazifylline do not reduce spontaneous locomotor activity in mice, nor do they produce overt symptoms of behavioral depression in conscious rats[1]. |
分子量 | 472.6 |
分子式 | C23H32N6O3S |
CAS No. | 79712-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (95.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.116 mL | 10.5798 mL | 21.1595 mL | 52.8989 mL |
5 mM | 0.4232 mL | 2.116 mL | 4.2319 mL | 10.5798 mL | |
10 mM | 0.2116 mL | 1.058 mL | 2.116 mL | 5.2899 mL | |
20 mM | 0.1058 mL | 0.529 mL | 1.058 mL | 2.6449 mL | |
50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.058 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(±)-Tazifylline 79712-55-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor (±) Tazifylline Tazifylline (±)Tazifylline Inhibitor inhibitor inhibit