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p53

p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN3404 Altholactone
化合物 TN3404
65408-91-5 98%
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2123 Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
槲皮素3-O-(6''-没食子酰基)-Β-D-半乳糖苷
53171-28-1 98%
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN4250 Imbricatolic acid
化合物 TN4250
6832-60-6 98%
Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells.
TN2114 Pseudoginsenoside Rh2
拟人参皂苷 Rh2
1370264-16-6 98%
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
TN3724 Cryptomoscatone D2
化合物 TN3724
276856-55-4 98%
Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
TN3525 Boehmenan
化合物 TN3525
57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN4774 Physalin A
化合物 TN4774
23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1688 Ginsenoside Rs3
人参皂苷RS3
194861-70-6 98%
Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
TN1875 Liriodenine
化合物Liriodenine
475-75-2 98%
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
TN5201 Uncarinic acid E
化合物 TN5201
277751-61-8 98%
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
T15016 CTX1
化合物 T15016
501935-96-2 98%
CTX1 is a small molecule activator of p53.
TN1617 Ergosta-4,6,8(14),22-tetraen-3-one
化合物Ergosta-4,6,8(14),22-tetraen-3-one
19254-69-4 98%
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN3719 Cristacarpin
化合物 TN3719
74515-47-2 98%
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
TN4341 IVHD-valtrate
化合物 TN4341
28325-56-6 98%
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
TN5050 Sprengerinin C
化合物 TN5050
88861-91-0 98%
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
TN3152 6-Acetonyldihydrochelerythrine
化合物 TN3152
22864-92-2 98%
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN4213 Hirsutenone
化合物 TN4213
41137-87-5 98%
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN1354 Aaptamine
化合物Aaptamine
85547-22-4 98%
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
化合物 TN3931
57719-81-0 98%
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN1156 (-)-Curine
左旋箭毒碱
436-05-5 98%
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
TN2123
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
Imbricatolic acid
TN4250
Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells.
Pseudoginsenoside Rh2
TN2114
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
Cryptomoscatone D2
TN3724
Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Ginsenoside Rs3
TN1688
Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
Liriodenine
TN1875
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
Uncarinic acid E
TN5201
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
CTX1
T15016
CTX1 is a small molecule activator of p53.
Ergosta-4,6,8(14),22-tetraen-3-one
TN1617
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
Cristacarpin
TN3719
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
IVHD-valtrate
TN4341
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
Sprengerinin C
TN5050
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
Aaptamine
TN1354
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
(-)-Curine
TN1156
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
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