Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T2434 | LY 303511
化合物LY 303511
|
154447-38-8 | 99.91% |
|
LY303511 是 LY294002 的结构类似物,可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性,还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流,IC50为64.6±9.1 μM。 | ||||
T79211 | MTOR inhibitor-11
化合物 mTOR inhibitor-11
|
98% |
|
|
mTORinhibitor-11(Compound 9)是具有穿透血脑屏障能力的mTOR抑制剂,其IC50针对pS6为21 nM。该化合物还可抑制pCHK1及PDE4D,其IC50值分别为17.2 μM和17.0 μM,适用于中枢神经系统疾病的研究。 | ||||
T79212 | MTOR inhibitor-12
化合物 mTOR inhibitor-12
|
98% |
|
|
mTORinhibitor-12(Compound 11)为选择性脑渗透性mTOR抑制剂,无遗传毒性风险,适用于中枢神经系统疾病研究。 | ||||
T80546 | Thioether-cyclized helix B peptide, CHBP
化合物 Thioether-cyclized helix B peptide, CHBP
|
1453840-35-1 | 98% |
|
Thioether-cyclized helix B peptide (CHBP) 通过抑制 mTORC1 及激活 mTORC2 诱导的自噬增强代谢稳定和肾脏保护效应。 | ||||
T80547 | Thioether-cyclized helix B peptide, CHBP TFA
化合物 Thioether-cyclized helix B peptide, CHBP TFA
|
98% |
|
|
Thioether-cyclized helix B peptide, CHBP(TFA)为Thioether-cyclized helix B peptide, CHBP的三氟乙酸盐形式,通过抑制mTORC1及激活mTORC2来诱导自噬(autophagy),进而增强代谢稳定性及肾脏保护效果。 | ||||
T81743 | MTORC1-IN-1
化合物 mTORC1-IN-1
|
98% |
|
|
mTORC1-IN-1(compound T1)为一种rapalog及选择性mTORC1抑制剂,调节细胞生长和代谢,与多种疾病如癌症相关。该化合物通过与FKBP12-FRB复合物结合(对接分数−11.6 kcal/mol)来靶向mTORC1。 | ||||
T81744 | MTOR inhibitor-14
化合物 mTOR inhibitor-14
|
98% |
|
|
mTORinhibitor-14(compound 14c)是一种mTOR高效抑制剂,对CYP2C8的抑制作用较弱,并能有效抑制肿瘤生长。 | ||||
T11328 | FT-1518
化合物 T11328
|
1313026-58-2 | 98% |
|
FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor. | ||||
TN3310 | 9,9'-Di-O-(E)-feruloylsecoisolariciresinol
化合物 TN3310
|
56973-66-1 | 98% |
|
1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer... | ||||
TN4788 | Pierreione B
化合物 TN4788
|
1292766-21-2 | 98% |
|
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cy... | ||||
T11742L | K-7174 dihydrochloride
化合物 T11742L
|
191089-60-8 | 98% |
|
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α... | ||||
TN2328 | Zeylenone
山椒子烯酮
|
193410-84-3 | 98% |
|
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。 | ||||
TN4382 | Kazinol A
化合物 TN4382
|
99624-28-9 | 98% |
|
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag... | ||||
T6346 | WYE-132
化合物WYE-125132
|
1144068-46-1 | 98% |
|
WYE-132 (WYE-125132) 是一种高度有效的 ATP 竞争性和特异性 mTOR 激酶抑制剂,IC50为 0.19±0.07 nM。它抑制 mTORC1和 mTORC2。 | ||||
TN5050 | Sprengerinin C
化合物 TN5050
|
88861-91-0 | 98% |
|
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st... | ||||
T12124 | MTOR inhibitor-2
化合物 T12124
|
2219323-96-1 | 98% |
|
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM). | ||||
T77629 | FD274
化合物FD274
|
2641899-38-7 | 98% |
|
FD274 是一种高效的 PI3K/mTOR 双重抑制剂,对 PI3Kα/β/γ/δ 和 mTOR 具有抑制作用, IC50 分别为 0.65 nM、1.57 nM、0.65 nM、0.42 nM 和 2.03 nM。 FD274 在 AML 细胞系抗增殖实验中显示出显着的抗增殖活性。 FD274 在 HL-60 异种移... | ||||
TN4356 | Jolkinolide A
化合物 TN4356
|
37905-07-0 | 98% |
|
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in... | ||||
TN4213 | Hirsutenone
化合物 TN4213
|
41137-87-5 | 98% |
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero... | ||||
TN1245 | 3-Deoxysappanchalcone
3-去氧苏木查尔酮
|
112408-67-0 | 98% |
|
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level. |