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HSP

HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T15088 Debio 0932
化合物 T15088
1061318-81-7 98%
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13076 Tamoxifen-​d5
化合物 T13076
157698-32-3 98%
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T78808 NDNA4
化合物 NDNA4
98%
NDNA4(compound 17)作为Hsp90α选择性抑制剂,具有0.34 μM的IC50值。作为永久带电的类似物,该化合物显示出低膜渗透性,并在Ovcar-8和MCF-10A细胞中表现出较低的细胞毒性(IC50>100 μM)。NDNA4能够保护hERG通道免遭破坏,同时不触发热休克反应或引起对Hsp90α依赖的客...
T78809 NDNA3
化合物 NDNA3
98%
NDNA3 (compound 14),一种选择性Hsp90α抑制剂,IC50为0.51 μM。该永久带电类似物具低膜渗透性,并对Ovcar-8细胞(IC50为12.66 μM)和MCF-10A细胞(IC50为11.72 μM)展现较低细胞毒性。NDNA3能够防止hERG通道成熟受损,不引发热休克反应或导致对Hsp90α...
T78863 HSP90-IN-25
化合物 HSP90-IN-25
98%
HSP90-IN-25 (化合物4a) 作为一种HSP90抑制剂,其作用机制为特异性抑制HSP90的ATPase活性。
T78942 HSP90-IN-23
化合物 HSP90-IN-23
98%
HSP90-IN-23 (Comp 12-1)为热休克蛋白90 (HSP90)的抑制剂,具有9 nM的IC50值。该化合物能够诱导肿瘤细胞凋亡,并抑制肿瘤细胞在G0/G1期的细胞周期。HSP90-IN-23常用于肿瘤学领域的研究。
T79083 HSP90-IN-22
化合物 HSP90-IN-22
442898-75-1 98%
HSP90-IN-22(Compound 35)作为Hsp90抑制剂,对MCF7乳腺癌细胞的IC50为3.65μM,对SKBr3乳腺癌细胞的IC50为2.71μM,显示出对这些细胞系具有显著的抗增殖活性。
T79285 TRAP1-IN-1
化合物 TRAP1-IN-1
98%
TRAP1-IN-1(化合物35)是一种高效、具有高选择性的TRAP1抑制剂,其中TRAP1为Hsp90蛋白质家族中的一种线粒体同源体。该抑制剂对TRAP1的选择性优于Grp94超过250倍,能够破坏TRAP1四聚体的稳定性,并诱导下游蛋白质的降解。此外,TRAP1-IN-1能够抑制线粒体氧化磷酸化复合体(OXPHOS)...
T79286 TRAP1-IN-2
化合物 TRAP1-IN-2
98%
TRAP1-IN-2(化合物36)作为TRAP1下游蛋白的选择性降解剂,不会对Hsp90的胞质下游蛋白产生影响。同时,该化合物还能抑制OXPHOS,导致细胞糖酵解代谢的变化。此外,TRAP1-IN-2会破坏TRAP1四聚体的稳定性,并影响线粒体膜电位。
T79323 PROTAC Hsp90α degrader 1
化合物 PROTAC Hsp90α degrader 1
98%
PROTACHsp90α degrader 1 (Compound X10g) 是一款选择性的PROTACHsp90α降解剂,专用于乳腺癌细胞研究。它对MDA-MB-231、MDA-MB-468、MCF-7、及MX-1等乳腺癌细胞系表现出显著的增殖抑制作用,其IC50s值分别为51.48 μM、16.46 μM、8.93...
T80742 Zelavespib hydrochloride
化合物 Zelavespib hydrochloride
98%
Zelavespib (PU-H71) hydrochloride is a potent Hsp90 inhibitor with an IC50 of 51 nM in MDA-MB-468 cells.
T82166 HSP90-IN-27
化合物 HSP90-IN-27
525577-38-2 98%
HSP90-IN-27(化合物19)是一种HSP90抑制剂。
T82167 HSP70/SIRT2-IN-2
化合物 HSP70/SIRT2-IN-2
1796557-72-6 98%
HSP70/SIRT2-IN-2(Compounds 1a)为针对SIRT2与HSP70的双重抑制剂,其IC50值为45.1±5.0 μM,展现了抗肿瘤活性。
T82802 BX-2819
化合物 BX-2819
1184181-50-7 98%
BX-2819为一种Hsp90抑制剂,具有41 nM 的IC50值,能有效抑制癌细胞增殖,并在裸鼠模型中显著抑制NCI-N87和HT-29肿瘤生长。
TN2360 Falcarinol
人参炔醇
21852-80-2 98%
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
T14905 CCT251236
化合物 T14905
1693731-40-6 98%
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
T73038 HSP90-IN-19
化合物 HSP90-IN-19
2927442-48-4 98%
HSP90-IN-19 是一种高效 Hsp90 抑制剂,其 IC50 值仅为 0.27 μM。该化合物在病毒感染、神经退行性疾病及炎症相关研究中具有潜在应用价值。
T73125 SMTIN-T140
化合物 SMTIN-T140
2851532-40-4 98%
SMTIN-T140(化合物6a)是一种TRAP1(肿瘤坏死因子受体相关蛋白1)的高效抑制剂,IC50值为1.646 μM。该化合物表现出显著的抗癌活性,可引起线粒体功能障碍,增加线粒体ROS产生以及激活AMPK。在PC3前列腺癌细胞异种移植的小鼠模型中,SMTIN-T140有效抑制了肿瘤生长,并显示出良好的体内安全性。...
T13547 AMP-PCP
化合物 T13547
3469-78-1 98%
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
TN3572 Calyxin H
化合物 TN3572
202596-22-3 98%
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
Debio 0932
T15088
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
Tamoxifen-​d5
T13076
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
NDNA4
T78808
NDNA4(compound 17)作为Hsp90α选择性抑制剂,具有0.34 μM的IC50值。作为永久带电的类似物,该化合物显示出低膜渗透性,并在Ovcar-8和MCF-10A细胞中表现出较低的细胞毒性(IC50>100 μM)。NDNA4能够保护hERG通道免遭破坏,同时不触发热休克反应或引起对Hsp90α依赖的客...
NDNA3
T78809
NDNA3 (compound 14),一种选择性Hsp90α抑制剂,IC50为0.51 μM。该永久带电类似物具低膜渗透性,并对Ovcar-8细胞(IC50为12.66 μM)和MCF-10A细胞(IC50为11.72 μM)展现较低细胞毒性。NDNA3能够防止hERG通道成熟受损,不引发热休克反应或导致对Hsp90α...
HSP90-IN-25
T78863
HSP90-IN-25 (化合物4a) 作为一种HSP90抑制剂,其作用机制为特异性抑制HSP90的ATPase活性。
HSP90-IN-23
T78942
HSP90-IN-23 (Comp 12-1)为热休克蛋白90 (HSP90)的抑制剂,具有9 nM的IC50值。该化合物能够诱导肿瘤细胞凋亡,并抑制肿瘤细胞在G0/G1期的细胞周期。HSP90-IN-23常用于肿瘤学领域的研究。
HSP90-IN-22
T79083
HSP90-IN-22(Compound 35)作为Hsp90抑制剂,对MCF7乳腺癌细胞的IC50为3.65μM,对SKBr3乳腺癌细胞的IC50为2.71μM,显示出对这些细胞系具有显著的抗增殖活性。
TRAP1-IN-1
T79285
TRAP1-IN-1(化合物35)是一种高效、具有高选择性的TRAP1抑制剂,其中TRAP1为Hsp90蛋白质家族中的一种线粒体同源体。该抑制剂对TRAP1的选择性优于Grp94超过250倍,能够破坏TRAP1四聚体的稳定性,并诱导下游蛋白质的降解。此外,TRAP1-IN-1能够抑制线粒体氧化磷酸化复合体(OXPHOS)...
TRAP1-IN-2
T79286
TRAP1-IN-2(化合物36)作为TRAP1下游蛋白的选择性降解剂,不会对Hsp90的胞质下游蛋白产生影响。同时,该化合物还能抑制OXPHOS,导致细胞糖酵解代谢的变化。此外,TRAP1-IN-2会破坏TRAP1四聚体的稳定性,并影响线粒体膜电位。
PROTAC Hsp90α degrader 1
T79323
PROTACHsp90α degrader 1 (Compound X10g) 是一款选择性的PROTACHsp90α降解剂,专用于乳腺癌细胞研究。它对MDA-MB-231、MDA-MB-468、MCF-7、及MX-1等乳腺癌细胞系表现出显著的增殖抑制作用,其IC50s值分别为51.48 μM、16.46 μM、8.93...
Zelavespib hydrochloride
T80742
Zelavespib (PU-H71) hydrochloride is a potent Hsp90 inhibitor with an IC50 of 51 nM in MDA-MB-468 cells.
HSP90-IN-27
T82166
HSP90-IN-27(化合物19)是一种HSP90抑制剂。
HSP70/SIRT2-IN-2
T82167
HSP70/SIRT2-IN-2(Compounds 1a)为针对SIRT2与HSP70的双重抑制剂,其IC50值为45.1±5.0 μM,展现了抗肿瘤活性。
BX-2819
T82802
BX-2819为一种Hsp90抑制剂,具有41 nM 的IC50值,能有效抑制癌细胞增殖,并在裸鼠模型中显著抑制NCI-N87和HT-29肿瘤生长。
Falcarinol
TN2360
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
CCT251236
T14905
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
HSP90-IN-19
T73038
HSP90-IN-19 是一种高效 Hsp90 抑制剂,其 IC50 值仅为 0.27 μM。该化合物在病毒感染、神经退行性疾病及炎症相关研究中具有潜在应用价值。
SMTIN-T140
T73125
SMTIN-T140(化合物6a)是一种TRAP1(肿瘤坏死因子受体相关蛋白1)的高效抑制剂,IC50值为1.646 μM。该化合物表现出显著的抗癌活性,可引起线粒体功能障碍,增加线粒体ROS产生以及激活AMPK。在PC3前列腺癌细胞异种移植的小鼠模型中,SMTIN-T140有效抑制了肿瘤生长,并显示出良好的体内安全性。...
AMP-PCP
T13547
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Calyxin H
TN3572
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
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