Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T11562 | HIF-2α-IN-3
化合物 T11562
|
313964-19-1 | 98% |
|
HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity. | ||||
T13402 | ZK-261991
化合物 T13402
|
886563-25-3 | 98% |
|
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2). | ||||
TN4603 | Myricanol
化合物 TN4603
|
33606-81-4 | 98% |
|
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis. | ||||
T12675 | (Rac)-PT2399
化合物 T12675
|
1672662-07-5 | 98% |
|
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM). | ||||
TN5250 | Vomifoliol
化合物 TN5250
|
23526-45-6 | 98% |
|
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ... | ||||
TN4489 | Manassantin A
化合物 TN4489
|
88497-87-4 | 98% |
|
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec... | ||||
T15234 | ENMD-1198
化合物 T15234
|
864668-87-1 | 98% |
|
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells. | ||||
T10258 | AFP464 free base
化合物 T10258
|
468719-52-0 | 98% |
|
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator. | ||||
TN1952 | Moracin P
桑辛素P
|
102841-46-3 | 98% |
|
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum... | ||||
T6804 | Chetomin
化合物Chetomin
|
1403-36-7 | 98% |
|
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。 | ||||
T36439 | Gramicidin A
杀螨素A
|
11029-61-1 | 98% |
|
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin ... | ||||
TN2040 | Panaxynol
人参炔醇
|
81203-57-8 | 98% |
|
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. | ||||
TN1951 | Moracin O
桑辛素O
|
123702-97-6 | 98% |
|
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9... | ||||
T2220 | 2-Methoxyestradiol
二甲氧基雌二醇
|
362-07-2 | 99.95% |
|
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。 | ||||
T13398 | ZINC13466751
化合物ZINC13466751
|
117953-17-0 | 99.94% |
|
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。 | ||||
T5740 | 25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元
|
874485-32-2 | 99.89% |
|
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。 | ||||
TN1480 | Cephaeline
吐根酚碱
|
483-17-0 | 99.88% |
|
Cephaeline 对受保护的原代 CLL 细胞具有高度活性(相对 IC50 为 35nM),并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。 | ||||
T2389 | Dapagliflozin
达格列净
|
461432-26-8 | 99.74% |
|
Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。 | ||||
T61822 | M1002
化合物M1002
|
823830-85-9 | 99.73% |
|
M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂,可以增强HIF-2alpha和ARNT对转录激活的亲和力 。M1002能够改变HIF-281alpha PAS-B结构域的Tyr2构象, 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。 | ||||
T19832 | Acriflavine Hydrochloride
盐酸吖啶黄
|
8063-24-9 | 99.69% |
|
Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。 |