Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
TN2217 | Sophoflavescenol
槐苦参醇
|
216450-65-6 | 99.65% |
|
Sophoflavescenol 是异戊烯基黄酮类化合物,能够抑制PDE5的活性,IC50=0.013 μM。它也抑制 RLAR,HRAR,BACE1,AChE 和 BChE,IC50值分别为 0.30 µM,0.17 µM,10.98 µM,8.37 µM 和 8.21 µM。 | ||||
TN3410 | Anatabine
化合物 TN3410
|
581-49-7 | 98% |
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime... | ||||
TN4865 | Putraflavone
化合物 TN4865
|
23624-21-7 | 98% |
|
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging. | ||||
TN2131 | Questin
化合物Questin
|
3774-64-9 | 98% |
|
Questin 是一种从花样黄曲霉中提取出来的抗菌剂,具有抗菌活型,对V. harveyi,V. anguillarum,V. cholerae 和 V. parahemolyticus 具有抑制作用,MIC 值分别为 31.25 µg/mL,62.5 µg/mL,62.5 µg/mL 和 125 µg/mL。Quest... | ||||
TN1332 | 7-O-Methylaloeresin A
7-O-甲基片木素A
|
329361-25-3 | 98% |
|
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE. | ||||
T10292 | AM-6494
化合物 T10292
|
1874232-80-0 | 98% |
|
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM). | ||||
T10450 | BACE1-IN-1
化合物 T10450
|
1310347-50-2 | 98% |
|
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2). | ||||
TN1434 | Bavachromene
补骨脂色烯查耳酮
|
41743-38-8 | 98% |
|
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro. | ||||
T8306 | Epiberberine chloride
表小檗碱氯化物
|
889665-86-5 | 98% |
|
Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱,是一种AChE 和BChE 抑制剂,和非竞争性的BACE1抑制剂。它具有抗氧化作用,能够清除 ONOO-,可用于研究阿尔滋海默症和糖尿病。 | ||||
T10452 | BACE1-IN-4
化合物 T10452
|
2361157-92-6 | 98% |
|
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. | ||||
T12429 | PF-06751979
化合物 T12429
|
1818339-66-0 | 98% |
|
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay). | ||||
T14338 | Atabecestat
化合物 T14338
|
1200493-78-2 | 98% |
|
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an... | ||||
TN4399 | Kushenol C
化合物 TN4399
|
99119-73-0 | 98% |
|
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).... | ||||
T10453 | BACE1-IN-5
化合物 T10453
|
2581114-83-0 | 98% |
|
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。 | ||||
T10451 | BACE1-IN-2
化合物 T10451
|
1352416-78-4 | 98% |
|
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM). | ||||
T6058 | LY2886721
化合物LY2886721
|
1262036-50-9 | 99.94% |
|
LY2886721 是选择性的,口服活性的 β 位淀粉样蛋白前体蛋白裂解酶 1 抑制剂,对重组人 BACE1的 IC50=20.3 nM。它对 BACE1的选择性高于对组织蛋白酶 D、胃蛋白酶、肾素的选择性,但缺乏对 BACE2的选择性。它可透过血脑屏障,并可用于研究阿尔茨海默氏病。 | ||||
T6772 | AZD3839 free base
化合物AZD3839
|
1227163-84-9 | 99.93% |
|
AZD3839 free base 是一种具有口服活性的、选择性的、可透过大脑屏障的BACE1抑制剂 (Ki=26 nM),对 BACE2 和组织蛋白酶 D 的选择性分别为 14 倍和 >1000 倍。在小鼠、豚鼠和非人灵长类动物中,它剂量和时间依赖性的降低血浆、脑和脑脊液 Aβ 水平,可用于研究阿尔茨海默病。 | ||||
T4398 | LX2343
化合物LX2343
|
333745-53-2 | 99.92% |
|
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。 | ||||
T83616 | SEW06622
化合物 SEW06622
|
261349-28-4 | 99.87% |
|
SEW06622 是一种有效的 乙酰胆碱酯酶(AChE)和β-分泌酶-1(BACE-1)抑制剂,是治疗阿尔茨海默病的潜在候选化合物。 | ||||
TN1343 | 8-Geranyloxypsoralen
8-香叶草氧基补骨脂素
|
7437-55-0 | 99.87% |
|
8-Geranyloxypsoralen 是一种呋喃香豆素,分离自葡萄柚,是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。 |