TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 380 | 5日内发货 | ||
50 μg | ¥ 1,170 | 5日内发货 | ||
500 μg | ¥ 5,130 | 5日内发货 | ||
1 mg | ¥ 6,720 | 5日内发货 |
产品描述 | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-hFc-6xHis |
蛋白编号 | O14763 |
别名 | DR5, TRAILR2, TRICK2, TNFRSF10B, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, Tumor Necrosis Factor Receptor Superfamily Member 10B, CD262, TRAIL-R2, Death Receptor 5, ZTNFR9, TRAIL Receptor 2 |
氨基酸序列 | Ile56-Glu182 |
蛋白构建 | Ile56-Glu182 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 49 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B. |
bottom
您可能有的问题的答案可以在重组蛋白操作手册中找到
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) TRAILR 2 DR5 TRAILR2 CD 262 TRICK2 TRICK 2 TRAILR-2 TNFRSF10B KILLER TNF-Related Apoptosis-Inducing Ligand Receptor 2 DR 5 Tumor Necrosis Factor Receptor Superfamily Member 10B CD262 TRICK-2 DR-5 TRAIL-R2 Death Receptor 5 ZTNFR-9 ZTNFR9 CD-262 ZTNFR 9 TRAIL Receptor 2 recombinant recombinant-proteins proteins protein