TIGIT Protein, Cynomolgus, Recombinant (hFc)

TIGIT Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.2 kDa and the accession number is A0A7N9I9V4.

规格	价格/CNY		数量
50 μg	￥ 2,260	现货
100 μg	￥ 3,970	5日内发货
200 μg	￥ 6,930	5日内发货
500 μg	￥ 14,440	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,260

现货

100 μg

￥ 3,970

5日内发货

200 μg

￥ 6,930

5日内发货

500 μg

￥ 14,440

5日内发货

生物活性	Immobilized human CD155/PVR Protein, Human, Recombinant (ECD, His Tag) at 2μg/mL (100μL/well) can bind TIGIT Protein, Cynomolgus, Recombinant (ECD, hFc Tag), the EC50 of TIGIT Protein, Cynomolgus, Recombinant (ECD, hFc Tag)(90890-C02H) is 5-30 ng/mL.
产品描述	TIGIT Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.2 kDa and the accession number is A0A7N9I9V4.

种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	A0A7N9I9V4
别名	T cell immunoreceptor with Ig and ITIM domains
蛋白构建	The cynomolgus TIGIT (XP_015300911.1) (Met1-Pro209) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	47.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy